接受规律健康教育的慢性乙型肝炎患者抑郁倾向及影响因素分析

Analysis of depression tendency and influencing factors in chronic hepatitis B patients receiving regular health education

目的:了解临床研究出组后持续接受规律健康教育的慢性乙型肝炎(CHB)患者抑郁倾向现状及影响因素。方法:选择临床研究接受门诊健康教育的CHB患者,以电话、短信、微信和QQ平台留言等多种方式告知患者返回门诊访视,采用患者健康问卷抑郁量表(PHQ-9)、广泛焦虑障碍量表(GAD-7)进行面对面问卷调查,Logictis回归分析影响抑郁倾向的相关因素。结果:本次调查到访CHB患者241例,纳入统计分析223例。单因素分析显示,持续接受规律的健康教育、焦虑、中医证候积分与CHB患者是否表现出抑郁倾向密切相关差异性有统计学意义(P<0.05)。多因素回归分析的结果显示,相对于中年组,青年组[OR=3.613,95%CI(1.415~9.221),P<0.01]、持续接受规律的健康教育[OR=0.353,95%CI(0.133~0.940),P<0.05]、有焦虑倾向[OR=11.333,95%CI(4.094~31.373),P<0.001]、中医症候积分(OR=1.171,95%CI 1.088~1.236,P<0.001)是患者抑郁倾向的影响因素。结论:持续接受规律的健康教育可降低CHB患者抑郁倾向的发生率,相对中年组患者,青年组焦虑、中医证候积分增加可增大抑郁倾向发生风险。

Objective:To investigate the status and influencing factors of depression tendency in patients with chronic hepatitis B(CHB)who had participated and re-participated in clinical research.Methods:CHB patients who received outpatient health education were selected for clinical study.They were told to return for outpatient visit by phone,SMS,Wechat and QQ platform.Face-to-face questionnaires were used to investigate the patients by Patient Health Questionnaire Depression Scale(PHQ-9)and Generalized Anxiety Disorder Scale(GAD-7).Logictis regression analysis was conducted to analyze the related factors affecting depression tendency.Results:241 were visited in this survey and 223 were included in statistical analysis.Univariate analysis showed that continue and regular health education,anxiety and TCM syndrome score had statistical significance on the differences of depression tendency(P<0.05).The results of multivariate regression analysis showed that,compared to middle-aged group,youth group[OR=3.613,95%CI(1.415-9.221),P<0.01],continue and regular health education[OR=0.353,95%CI(0.133-0.940),P<0.05],anxiety tendency[OR=11.333,95%CI(4.094-31.373),P<0.001],TCM syndrome score[OR=1.171,95%CI(1.088-1.236),P<0.001]were the influencing factors of depression tendency.Conclusion:Continue and regular health education can reduce the incidence of depression.Compared to middle-aged group,the increase of youth group,anxiety and TCM syndrome score can increase the risk of depression.