糖尿病性勃起功能障碍与细胞凋亡的研究进展

A review on diabetic mellitus-induced erectile dysfunction and apoptosis

糖尿病性勃起功能障碍(Diabetes Mellitus-induced Erectile Dysfunction,DMED)是指继发于糖尿病的男性勃起功能障碍。此病表现为阴茎持续不能达到和维持足够勃起硬度以获得满意的性生活。作为糖尿病常见的微血管并发症之一,其发病原因复杂,发病机制尚不明确。通常认为,此病由多种相互关联的机制引起,包括内皮细胞紊乱、氧化应激、自主神经病变等。近年研究发现,糖尿病患者长期高血糖会导致与勃起功能关系密切的神经、血管内皮、海绵体平滑肌、睾丸等组织细胞凋亡,进而引发勃起功能障碍。文章以细胞凋亡为切入点,结合细胞凋亡途径相关通路,综述近年来细胞凋亡在DMED中的研究进展,旨在为临床防治DMED提供新思路。

Diabetic mellitus-induced erectile dysfunction(DMED)is an erectile dysfunction in men secondary to diabetes mellitus(DM),manifested by a persistent inability to achieve and maintain sufficient erectile hardness of the penis for satisfactory sexual intercourse.As one of the common microvascular complications of diabetes mellitus,its pathogenesis is complex and the pathogenesis is unclear.It is generally believed that this disease is caused by a variety of interrelated mechanisms,including endothelial cell disorder,oxidative stress,autonomic neuropathy,etc..Recent studies have found that the long-term hyperglycemic state of DM patients will lead to apoptosis of nerve,vascular endothelium,cavernous smooth muscle,and testis,which are closely related to erectile function,thus causing erectile dysfunction.Therefore,in this paper,we take apoptosis as the starting point and review the research progress of apoptosis in DMED in recent years,aiming to provide new ideas to guide clinical prevention and treatment.