ω-3多不饱和脂肪酸防治心律失常临床研究进展

Advances in Clinical Research ofω-3 Polyunsaturated Fatty Acids in Prevention and Treatment of Arrhythmias

ω-3多不饱和脂肪酸(ω-3PUFAs)的主要膳食来源是鱼类,ω-3PUFAs包括二十碳五烯酸(EPA)和二十二碳六烯酸(docosahexaenoic acid,DHA)。有研究认为,ω-3PUFAs可影响室性心律失常和心脏猝死。最近的研究还表明,其可能影响心房颤动。该文旨在回顾最近发表的研究,总结目前ω-3PUFAs在预防室性心律失常、心源性猝死和心房颤动方面临床作用的现有证据。ω-3PUFAs可以防止室性心律失常,且越来越多的证据表明ω-3PUFAs有预防和治疗房颤方面的作用。目前,还需要进一步研究来确定哪些患者更有可能受益于ω-3PUFAs,以及其治疗时间和剂量。

The main dietary source ofω-3 polyunsaturated fatty acids(PUFAs)is fish.Theω-3PUFAs includ eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA).It has been suggested that marineω-3PUFAs affects ventricular arrhythmia,sudden cardiac death,and more recently,possible effects on atrial fibrillation.Based on recently published studies,the present paper aimed to review the evidence on the clinical roleω-3PUFAs in preventing ventricular arrhythmia,sudden cardiac death,and atrial fibrillation.It was concluded thatω-3PUFAs might protect against ventricular arrhythmias,and there was growing evidence on the effect of marineω-3PUFAs in preventing and treating atrial fibrillation.Further studies are needed to determine which patients are more likely to benefit fromω-3PUFAs,and the timing and dose of treatment.