一氧化氮调控线粒体功能在疾病中的作用

Role of nitric oxide in regulating the mitochondrion function in diseases

一氧化氮是机体内重要的气体信号分子,广泛分布于体内各组织中,参与多种生理病理过程的调节。线粒体作为细胞代谢和细胞内信号传导的中心枢纽,其功能障碍会导致多种疾病的发生,包括心血管疾病、神经系统变性疾病、肿瘤、炎症等。近年来,越来越多的研究表明一氧化氮可作为线粒体的调控因子,影响线粒体功能和细胞活性,进而介导疾病的发生与发展。本文就一氧化氮通过调控线粒体功能参与疾病的发病机制展开综述,旨在为疾病的预防和治疗提供新的思路。

Nitric oxide has been highlighted as an important gas signaling molecule in the body,widely distributed in various tissues and involved in the regulation of various physiological and pathological processes.Mitochondrion,as the central hub of cellular metabolism and intracellular signal transduction,their dysfunction may cause various diseases,including cardiovascular diseases,neurological diseases,tumors,inflammation,etc.In recent years,more and more studies have shown that nitric oxide may act as a regulatory factor in mitochondria,affect the mitochondrial function and cell activity,and then mediate the development of diseases.This article reviewed the involvement of nitric oxide in the pathogenesis of diseases by regulating the mitochondrial function,aiming to provide new ideas for disease prevention and treatment.