NAD(H)调控线粒体功能在疾病中的作用

Role of NAD(H)in regulating the mitochondrion function in diseases

线粒体是细胞内最重要的细胞器之一,不仅作为能量合成器在细胞代谢中发挥着重要作用,也通过介导SIRTs、PARPs等多种酶的功能参与细胞信号传导。NAD(H)是活细胞中的辅酶,可作为线粒体的调控因子广泛参与调节细胞生长、分化、能量代谢、凋亡等生物学过程,从而影响疾病的发生与发展。本文综述NAD(H)调控线粒体功能的分子机制,并简述NAD(H)的合成、消耗与检测方法,阐述其在神经系统变性疾病、衰老、肿瘤和心血管疾病等状态下的调控机制和潜在的药物靶点特性,旨在为NAD(H)介导的疾病预防和诊疗提供新的思路。

Mitochondria are one of the most important organelles in the cells,playing a crucial role in energy synthesis in cell metabolism and participating in cell signaling through the action of various enzymes such as SIRTs and PARPs.NAD(H)is a coenzyme in living cells and extensively participates in regulating biological processes such as the cell growth,differentiation,energy metabolism,and apoptosis as regulatory factors of mitochondria,thereby affecting the occurrence and development of diseases.This article reviewed the molecular mechanism of NAD(H)in regulating mitochondrion function and the synthesis,consumption,and detection of NAD(H).It also explained the regulatory mechanism and potential drug target characteristics of NAD(H)in aging,tumors,and neurodegenerative diseases,aiming to provide new insight for disease prevention and diagnosis of NAD(H).