益生菌分别联合瑞素及百普力肠内营养支持治疗在脑出血术后患者中的应用价值对比

Comparison of the application value of probiotics combined with rexine and peptisonide enteral nutrition support in patients with cerebral hemorrhage after operation

目的对比益生菌分别联合瑞素及百普力肠内营养支持治疗在脑出血术后患者中的应用价值。方法选取2017年7月至2021年3月本院收治的56例脑出血术后患者作为研究对象,按照随机数字表法分为观察组与对照组,每组28例。对照组采用益生菌联合瑞素肠内营养支持,观察组采用益生菌联合百普力肠内营养支持,比较两组免疫球蛋白、D-乳酸、降钙素原(PCT)水平及不良反应发生情况。结果治疗前,两组IgA、IgG、IgM水平比较差异无统计学意义;治疗后,两组IgA、IgG、IgM水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组D-乳酸、PCT水平比较差异无统计学意义;治疗后,两组D-乳酸水平均低于治疗前,观察组PCT水平低于治疗前,且观察组D-乳酸、PCT水平均低于对照组,差异有统计学意义(P<0.05);对照组治疗前后PCT水平比较差异无统计学意义。两组呕吐、胃潴留、消化道出血发生率比较差异无统计学意义;观察组腹泻、便秘发生率均低于对照组,差异有统计学意义(P<0.05)。结论益生菌联合百普力肠内营养支持治疗脑出血术后患者效果显著,可提高患者免疫功能,降低其血清D-乳酸、PCT水平,同时,还提高患者胃肠道耐受性,值得临床推广应用。

Objective To compared the application value of probiotics combined with rexine and peptisonide enteral nutrition support in patients with cerebral hemorrhage after operation.Methods 56 patients treated in our hospital from July 2017 to March 2021 after intracerebral hemorrhage operation were selected as research subjects,and they were divided into the observation group and the control group according to the random number table method,with 28 cases in each group.The control group was given probiotics combined with rexine enteral nutrition support,and the observation group was given probiotics combined with peptisonide enteral nutrition support.The levels of immunoglobulin,D-lactic acid,procalcitonin(PCT)and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there were no statistically significant differences in the levels of IgA,IgG and IgM between the two groups;after,the levels of IgA,IgG and IgM of two groups were higher than before treatment,and the the observation group was higher than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of D-lactic acid and PCT between the two groups;after treatment,the levels of D-lactic acid of two groups were lower than those before treatment,and the level of PCT in the observation group was lower than that before treatment,and the levels of D-lactic acid and PCT in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in PCT level before and after treatment in the control group.There was no significant difference in the incidence of vomiting,gastric retention and gastrointestinal bleeding between the two groups;the incidence of diarrhea and constipation in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).Conclusion Probiotics combined with peptisonide enteral nutrition support has significant effect in the treatment of patients with cerebral hemorrhage after operation,which can improve the immune function of patients,reduce the levels of serum D-lactic acid and PCT,and also improve the gastrointestinal tolerance of patients,which is worthy of clinical promotion and application.