阿司匹林联合硫酸氢氯吡格雷治疗急性缺血性脑卒中的效果

Application effect of aspirin combined with clopidogrel hydrogen sulfate in the treatment of acute ischemic stroke

目的探讨阿司匹林联合硫酸氢氯吡格雷治疗急性缺血性脑卒中的效果。方法选取2018年9月至2020年9月本院收治的80例急性缺血性脑卒中患者作为研究对象,按照随机数字表法分为对照组与研究组,各40例。对照组给予阿司匹林治疗,研究组给予阿司匹林联合硫酸氢氯吡格雷治疗。比较两组氧化应激指标、脂质过氧化指标、神经功能缺损程度及不良反应发生情况。结果治疗前,两组超氧化物歧化酶(SOD)、丙二醛(MDA)、异构前列腺素(iso-PGs)水平比较差异无统计学意义;治疗30 d后,两组MDA水平均低于治疗前,iso-PGs水平均高于治疗前,研究组SOD水平高于治疗前,且研究组MDA、iso-PGs水平均低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05),对照组治疗前后SOD水平比较差异无统计学意义。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义;治疗30 d后,两组NIHSS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论阿司匹林联合硫酸氢氯吡格雷治疗急性缺血性脑卒疗效显著,可促进患者神经功能恢复,缓解氧化应激反应及脂质过氧化,安全性较高,值得临床推广应用。

Objective To explore the application effect of aspirin combined with clopidogrel hydrogen sulfate in the treatment of acute ischemic stroke.Methods 80 patients with acute ischemic stroke admitted to our hospital from September 2018 to September 2020 were selected as the research subjects,and they were divided into the control group and the study group according to the random number table method.The control group received aspirin treatment,while the study group received aspirin combined with clopidogrel hydrogen sulfate treatment.The oxidative stress indicators,lipid peroxidation indicators,degree of neurological function deficit and occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of superoxide dismutase(SOD),malondialdehyde(MDA),and isoprostanes(iso-PGs)between the two groups;after 30 d of treatment,MDAlevel of the two groups was lower than before treatment,iso PGs level was higher than before treatment,SOD level in the study group was higher than before treatment,MDA and iso-PGs levels in the study group were lower than the control group,SOD level was higher than the control group,and the differences were statistically significant(P<0.05),there was no significant difference in SOD level in control group before and after treatment.Before treatment,there was no statistically significant difference in the National Institutes of Health stroke scale(NIHSS)scores between the two groups;after 30 d of treatment,the NIHSS scores of the two groups were lower than before treatment,and the study group was lower than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Aspirin combined with clopidogrel bisulfate is effective in the treatment of acute ischemic cerebral infarction,can promote the recovery of nerve function,relieve oxidative stress and lipid peroxidation,and is safe,worthy of clinical promotion and application.