百令胶囊联合二甲双胍治疗糖尿病肾病疗效及对血清ACA IL-6 NGAL水平的影响

Efficacy of Bailing Capsule Combined with Metformin in the Treatment of Diabetic Kidney Disease and Its Influence on Levels of Serum ACA IL-6 and NGAL

目的:百令胶囊联合二甲双胍治疗糖尿病肾病(DKD)的效果分析。方法:选择2019年1月至2020年7月符合要求的108例患者,经简单随机化分组法分为百令胶囊组(n=54)和常规组(n=54)。常规组接受丹参多酚酸盐联合二甲双胍及其他DKD常规治疗;在常规组的基础上给予百令胶囊组百令胶囊联合治疗。比较两组患者治疗前及治疗16周时的血糖指标、肾功能指标、血清相关因子及血管内皮功能指标水平;比较两组患者治疗16周时的临床疗效。结果:两组患者治疗前的血糖指标(FPG、2hPG、HbA1c、HOMA-IR)、肾功能指标(Scr、BUN、24hUAER)、血清相关因子(ACA-IgA、ACA-IgM、ACA-IgG、NGAL)水平比较无显著差异(P均>0.05),治疗16周时两组患者的上述指标较治疗前明显降低,且百令胶囊组降低幅度更大(P均<0.05);治疗16周时百令胶囊组患者的ET-1水平显著低于常规组,且其降低幅度更大(P均<0.05)。治疗16周时百令胶囊组NO水平及FMD、NMD值显著高于常规组,且其升高幅度更大(P均<0.05),且其临床疗效较常规组明显改善(Z=2.123,P=0.034)。结论:在DKD患者常规治疗的基础上联合百令胶囊治疗,可有效调节患者的血糖代谢,缓解炎性反应,改善肾功能,提高治疗效果。

Objective:To analyze the effects of Bailing capsule combined with metformin in the treatment of diabetic kidney disease(DKD).Methods:A total of 108 patients who met the requirements were selected between January 2019 and July 2020,and simple randomized grouping method was used to divide the patients into Bailing capsule group(n=54)and conventional group(n=54).The conventional group was given salvianolate combined with metformin and other conventional DKD treatments,and the Bailing capsule group was combined with Bailing capsule on the basis of the regular group.The blood glucose indicators,renal function indicators,serum-related factors,and vascular endothelial function indicators were compared between the two groups of patients before treatment and at 16 weeks of treatment.The clinical efficacy of the two groups of patients was compared at 16 weeks of treatment.Results:There were no significant differences in the levels of blood glucose indicators(FPG,2hPG,HbA1c,HOMA-IR),renal function indicators(Scr,BUN,24h UAER)and serum-related factors(ACA-IgA,ACA-IgM,ACA-IgG,NGAL)between the two groups of patients before treatment(all P>0.05),and at 16 weeks of treatment,the above indicators of the two groups were significantly decreased compared with those before treatment,and the decreases were greater in Bailing capsule group(all P<0.05).The level of ET-1 of Bailing capsule group at 16 weeks of treatment was significantly lower than that of conventional group,and the decline was greater(all P<0.05).The NO,FMD and NMD of Bailing capsule group were significantly higher than those of conventional group at 16 weeks of treatment,and the increases were greater(all P<0.05),and its clinical efficacy was significantly improved compared to conventional group(Z=2.123,P=0.034).Conclusion:On the basis of conventional treatment of patients with DKD,combination of Bailing capsule can effectively regulate the glucose metabolism level,relieve the inflammatory response,improve the renal function,and enhance the therapeutic effect.