抗HPV生物蛋白敷料联合藤甲酸氯化钠和重组人干扰素α2b治疗子宫颈鳞状上皮内病变HPV感染的效果研究

Efficacy of Anti-HPV Bioprotein Dressings Combined with Garcinic Acid Sodium Chloride and Recombinant Human Interferonα2b in the Treatment of HPV Infection in Cervical Squamous Intraepithelial Lesions

目的综合分析抗人乳头瘤病毒(human papillomavirus,HPV)生物蛋白敷料联合藤甲酸氯化钠和重组人干扰素α2b(recombinant human interferonα-2b,rhIFN-α2b)治疗子宫颈鳞状上皮内病变HPV感染的效果。方法选取2022年9月—2023年3月牡丹江医学院附属红旗医院妇科收治的100例子宫颈鳞状上皮内病变HPV感染患者为研究对象,采用随机数表法分为对照组和研究组,各50例。对照组采用rhIFN-α2b栓剂治疗,研究组在对照组的基础上采用抗HPV生物蛋白敷料以及藤甲酸氯化钠进行治疗。观察并比较两组HPV转阴情况、菌群恢复情况、不良反应发生情况以及治疗后白介素-4(interleukin-4,IL-4)、白介素-12(interleukin-12,IL-12)和干扰素-γ(interferon gamma,IFN-γ)水平。结果研究组的HPV转阴率(90.00%)高于对照组(72.00%),差异有统计学意义(χ^(2)=5.263,P<0.05)。研究组的菌群恢复情况、不良反应发生情况以及治疗后的IL-4、IL-12、IFN-γ水平均优于对照组,差异有统计学意义(P<0.05)。结论在子宫颈鳞状上皮内病变HPV感染中使用抗HPV生物蛋白敷料、rhIFN-α2b联合藤甲酸氯化钠具有较为积极的意义,能够提高患者预后。

Objective To analyze the effect of anti-human papillomavirus(HPV)bioprotein dressing combined with sodium chloride tenginate and recombinant human interferonα2b(rhIFN-α2b)in the treatment of HPV infection in cervical squamous intraepithelial lesions.Methods A total of 100 cases of HPV infected patients admitted to the gynecology department of Hongqi Hospital Affiliated to Mudanjiang Medical Col-lege from September 2022 to March 2023 were selected as the study objects,and were divided into control group and study group by random number table method,with 50 cases in each group.The control group was treated with rhIFN-α2b suppository,and the study group was treated with anti-HPV biological protein dressing and sodium chloride tenginate on the basis of the control group.Observed and compared the HPV negative conversion,bacterial recovery,adverse reactions,and the level of interleukin-4(IL-4),interleukin-12(IL-12)and inter-feron-γ(IFN-γ)after treatment between the two groups.Results The negative conversion rate of HPV in the study group(90.00%)was higher than that in the control group(72.00%),and the difference was statistically significant(χ^(2)=5.263,P<0.05).The microflora recovery,the occur-rence of adverse reactions,and the levels of IL-4,IL-12 and IFN-γafter treatment in the study group were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of anti-HPV bioprotein dressings and rhIFN-α2b in com-bination with sodium chloride of tenoconic acid has positive significance and can improve the prognosis of HPV infection in cervical squa-mous intraepithelial lesions.