星形胶质细胞介导的神经炎症在抑郁症发生发展中的作用

The Role of Astrocyte-Mediated Neuroinflammation in the Onset and Development of Depression

抑郁症是一种常见的损害严重的精神疾病,其发病机制尚未完全阐明。目前关于抑郁症的发病机制存在多种假说,最新研究显示神经炎症与抑郁症发生发展密切相关。随着神经科学技术的发展,星形胶质细胞在抑郁症中的作用越来越受到关注。有研究表明,抑郁症与星形胶质细胞介导的神经炎症有关,小胶质细胞、NF-κB信号通路、NLRP炎症小体均参与其中,为抑郁症的治疗提供了可能的靶点。本文主要综述了星形胶质细胞介导的神经炎症与抑郁症相关的研究进展。

Depression is a common and serious psychiatric disorder,the pathogenesis of which remains incompletely elucidated.Currently,there are several hypotheses about the pathogenesis of depression,and the latest evidence suggests that neuroinflammation is closely associated with the onset and development of depression.With the advancement of neuroscientific technology,the role of astrocytes in depression has been receiving increasing attention.Studies have shown that depression is associated with astrocyte-mediated neuroinflammation,in which microglia,the NF-κB signaling pathway,and NLRP inflammasomes are involved,providing potential targets for the treatment of depression.In this article,we review the research progress on astrocyte-mediated neuroinflammation associated with depression.