外泌体在铁死亡相关疾病中的作用及靶向治疗策略研究进展

Role of exosomes in ferroptosis-related diseases and targeted therapeutic strategies: research progress

铁死亡是一种铁依赖性非细胞凋亡的程序性细胞死亡方式。迄今为止,铁死亡已被证明参与了许多疾病的病理生理机制,如神经退行性疾病、缺血/再灌注损伤和肿瘤等。外泌体作为细胞间的信息传递途径,已被证明在铁死亡进程中具有重要调控意义。同时,外泌体作为一种免疫原性低、生物相容性好、效率高的药物传递载体,在疾病治疗中的应用愈发广泛。本文总结了近年外泌体在铁死亡相关疾病发生机制中的调控作用及以铁死亡为靶点的新型外泌体治疗策略的研究进展。

Ferroptosis is an iron-dependent,non-apoptotic programmed cell death pattern.So far ferroptosis has been proved to be involved in the pathophysiological mechanisms of many diseases,such as neurodegenerative diseases,ischemia/reperfusion injury,and tumors.Exosomes,as an intercellular messaging pathway,have been reported to play an important role in regulating ferroptosis process.Meanwhile,exosomes are increasingly used in diseases as a drug delivery vehicle due to low immunogenicity,good biocompatibility,and high efficiency.This article summarizes the regulatory role of exosomes in ferroptosis-related diseases and novel exosome therapeutic strategies targeting ferroptosis.