环境内分泌干扰物在变应性鼻炎发病机制中的作用研究

Role of the pathogenesis of allergic rhinitis caused by environmental endocrine disrupting chemicals

变应性鼻炎(AR)的发病率逐年上升,其发病与环境因素密不可分,其中,环境内分泌干扰物(EDCs)是一类可干扰内源性激素的典型环境污染物,流行病学研究显示AR发病与EDCs暴露有一定的关联性。EDCs在AR发病机制中的作用已有探索性研究,EDCs可通过作用于激素信号通路,促进氧化应激和气道炎症,打破辅助型T细胞(Th)1/Th2平衡,引起微生物群失调,调控表观遗传调控等途径引起呼吸道变应性炎性反应,说明EDCs暴露可能是诱发AR的一个重要因素。本文就EDCs来源、分类、污染现状、特性及对AR发病的影响和可能的作用机制进行综述。

The incidence of allergic rhinitis(AR)is increasing year by year,which is closely related to environmental factors.Among them,environmental endocrine disrupting chemicals(EDCs)are typical environmental pollutants,which can interfere with endogenous hormones.Epidemiological studies have shown that there is a certain correlation between the incidence of AR and EDCs exposure.The role of EDCs in the pathogenesis of AR has been explored.EDCs can promote oxidative stress and airway inflammation by acting on hormone signaling pathways,break the balance of Th1(Thelper cell 1)/Th2(Thelper cell 2),cause microbiota imbalance,regulate epigenetic regulation and other pathways to cause respiratory allergic inflammatory response.The EDCs exposure may be an important factor in inducing AR.In this paper,it will be reviewed for the source,classification,pollution status,characteristics and possible mechanism of EDCs about AR.