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偏头痛病人MHR与疾病严重程度和脑白质高信号的相关性分析

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摘要 目的:分析偏头痛病人单核细胞/高密度脂蛋白胆固醇(HDL-C)比值(MHR)与疾病严重程度和脑白质高信号(WMHs)的相关性。方法:选取100例偏头痛病人(其中57例无WMHs,43例有WMHs)和100名健康体检者。采用视觉模拟评分法(VAS)测定疼痛强度,采用偏头痛残疾评估量表(MIDAS)测定致残情况。采集血液样本进行生化检测,并计算MHR比值。采用Pearson法进行相关性分析。结果:偏头痛组单核细胞计数、MHR高于对照组,HDL-C水平低于对照组,差异有统计学意义(P<0.05)。WMHs组中性粒细胞计数、单核细胞计数、三酰甘油、MHR及MIDAS评分、VAS评分、头痛持续时间均高于无WMHs组,HDL-C水平低于无WMHs组,差异有统计学意义(P<0.05)。偏头痛病人MHR与WMHs、MIDAS评分和VAS评分呈正相关(P<0.01)。受试者工作特征(ROC)曲线分析MHR预测偏头痛截断值为12.8,敏感度为78.9%,特异度为94.7%,ROC曲线下面积为0.894。结果:偏头痛病人MHR与疾病严重程度和WMHs有相关性。
机构地区 吕梁市人民医院
出处 《中西医结合心脑血管病杂志》 2023年第20期3853-3856,共4页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 山西医科大学第十一临床医学院基金项目(No.LY0232020YL-9) 吕梁市重点研发项目(No.2021SHFZ-2-44)。
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