CEUS时间-强度曲线定量模型在宫颈癌同步放化疗中的应用价值

The application value of CEUS time-intensity curve quantitative model in cervical cancer concurrent chemoradiotherapy

目的:探讨超声造影(contrast-enhanced ultrasound,CEUS)时间-强度曲线(time intensity curve,TIC)定量模型在中晚期宫颈癌患者同步放化疗(concurrent chemoradiotherapy,CCRT)效果评估中的临床价值。方法:选取2018年8月—2020年8月于江苏省肿瘤医院放疗科住院接受CCRT治疗的中晚期宫颈癌患者16例,所有患者在接受治疗前、治疗2周和外照射结束后行经阴道CEUS检查,并采用CEUS联合TIC定量模型进行分析。结果:整体患者及TP方案组CCRT治疗2周和外照射结束后达峰时间分别较治疗前明显缩短;TP方案组CCRT治疗2周曲线下面积较治疗前明显增加。结论:CEUS联合TIC能够体现中晚期宫颈癌CCRT治疗后肿瘤内部血流灌注变化情况,具有一定的早期疗效评估价值。

Objective:To investigate the clinical value of the quantitative model of contrast-enhanced ultrasound(CEUS)timeintensity curve(TIC)in the evaluation of the therapeutic efficacy during concurrent chemoradiotherapy(CCRT)for advanced cervical cancer.Methods:Sixteen patients with advanced cervical cancer who received CCRT in the Department of Radiation Oncology at Jiangsu Cancer Hospital from August 2018 to August 2020 were selected.All patients underwent transvaginal CEUS before treatment,at 2 weeks of treatment,and after completion of external irradiation.CEUS combined with TIC quantitative analysis was conducted.Results:Both the overall patient group and TP group showed significantly shortened time to peak enhancement at 2 weeks into CCRT treatment and after external irradiation compared to before treatment.The TP group exhibited a significant increase in the area under the curve at 2 weeks into treatment compared to before treatment.Conclusion:The combined use of CEUS and TIC analysis can reflect changes in tumor perfusion after CCRT treatment for advanced cervical cancer,providing a certain value in early therapeutic efficacy assessment.