封闭负压引流技术联合降钙素原动态监测在坏死性筋膜炎中的应用

Application of vacuum sealing drainage and dynamic procalcitonin monitoring in necrotizing fasciitis

目的 观察封闭负压引流技术(VSD)联合降钙素原(PCT)动态监测在坏死性筋膜炎中的应用价值。方法92例坏死性筋膜炎患者随机分为观察组和对照组,两组均采用VSD治疗,对照组依据临床经验使用抗菌药物,观察组依据PCT浓度使用抗菌药物。比较两组的治疗指标、炎性因子、抗菌药物使用和住院费用。结果 与对照组比较,观察组创面愈合率高,住院时间短,治疗后hs-CRP、IL-8、IFN-γ水平低,抗菌药物疗程少,住院费用低(P<0.01或0.05)。结论VSD联合PCT动态监测可优化坏死性筋膜炎患者抗菌药物的使用,提高创面愈合率。

Objective To observe the application value of vacuum sealing drainage(VSD) and dynamic procalcitonin(PCT) monitoring in necrotizing fasciitis.Methods Ninety-two patients with necrotizing fasciitis undergoing VSD were randomized to observation and control groups.Antibiotic usage was based on clinical experience in control group and PCT level in observation group.The treatment indexes,inflammatory factors,antibiotic usage and hospitalization expense were compared between of two groups.Results Compared with control group,wound healing rate was higher,while hospitalization time and expense,course of antibiotic usage,and levels of hs-CRP,IL-8 and IFN-γ were lower in observation group(P<0.01 or 0.05).Conclusion Combined use of VSD and dynamic PCT monitoring can improve antibiotic usage and wound healing rate in necrotizing fasciitis.