摘要
近年来,一系列研究发现轴突生长抑制因子(Nogo)蛋白在多种疾病中发挥重要作用。此外,Nogo还通过介导巨噬细胞M1/M2极化参与炎症进程。该文综述了Nogo家族在疾病中的作用并揭示其分子机制。
In recent years,a series of studies have found that neurite outgrowth inhibitor(Nogo) proteins play an important role in a variety of diseases.In addition,Nogo is actively involved in the inflammatory process by mediating M1/M2polarization of macrophages.This paper reviewed the role of Nogo family in diseases and revealed its molecular mechanism.
作者
张艳
徐浩森
蒋欢
兰金意
杨单植
刘沛敏
白晓燕
ZHANG Yan;XU Hao-sen;JIANG Huan;LAN Jin-yi;YANG Shan-zhi;LIU Pei-min;BAI Xiao-yan(The First School of Clinical Medicine,Guangdong Medical University,Zhanjiang 524023,China;Department of Nephrology,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Guangzhou 510080,China)
出处
《广东医科大学学报》
2023年第5期574-578,共5页
Journal of Guangdong Medical University
基金
国家自然科学基金面上项目(82170730,81873616)。
关键词
轴突生长抑制因子
肾脏疾病
心血管疾病
肝脏疾病
巨噬细胞
neurite outgrowth inhibitor
kidney diseases
cardiovascular diseases
liver diseases
macrophage
