MALAT1基因调控的信号通路在癌症发生发展中的作用

Role of MALAT1 gene regulated signaling pathways in cancer incidence and progression

肺腺癌转移相关转录物1(MALAT1)可通过调节选择性剪接、基因转录以及充当miRNA海绵发挥其分子作用,并与人类肿瘤的转移、临床分期、复发、预后及化疗耐药机制密切相关。该文主要综述MALAT1基因表达调控的信号通路在癌症发生、发展中的作用。

Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) plays its molecular role by regulating selective splicing,gene transcription,and acting as a miRNA sponge.It is closely related to human tumor metastasis,clinical staging,relapse,prognosis,and chemotherapy resistance mechanisms.This paper mainly reviewed the role of signaling pathways regulated by MALAT1 gene expression in cancer incidence and progression.