骨质疏松性椎体压缩骨折患者椎体成形术后血脂水平与延迟愈合的关系

The Relationship between Blood Lipid Level and Delayed Healing in Patients with Osteoporotic Vertebral Compression Fractures after Vertebroplasty

目的探讨骨质疏松性椎体压缩骨折患者椎体成形术后血脂水平与延迟愈合的关系。方法:前瞻性研究,选取开封市第二中医院骨科2019年8月-2021年12月收治的骨质疏松性椎体压缩骨折患者为研究对象,共纳入140例。于患者入院时,通过基线资料调查表统计患者基本资料。给予所有对象椎体成形术治疗。统计术后3个月时患者的骨折愈合情况,将延迟愈合的患者纳入发生组,其余患者纳入未发生组。比较两组患者基线资料、骨水泥量、麻醉方式、骨密度、术后视觉模拟评分量表(VAS)评分、血脂水平等指标,研究血脂水平与骨折延迟愈合的关系。结果术后3个月,140例骨质疏松性椎体压缩骨折患者术后发生延迟愈合11例,占比7.86%;未发生组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)指标对比,差异有统计学意义(P<0.05)。两组年龄、体重、VAS评分、麻醉方式等资料对比(P>0.05);经点二列相关结果显示,术后血脂水平与骨质疏松性椎体压缩骨折患者后延迟愈合呈正相关(r>0,P<0.05);经Logistic回归分析,结果显示,TG、TC、LDL-C升高与骨质疏松性椎体压缩骨折患者椎体成形术后延迟愈合发生有关(OR>1,P<0.05)。结论骨质疏松性椎体压缩骨折患者椎体成形术后血脂(TC、TG、LDL-C)水平与延迟愈合有关。

Objective To investigate the relationship between blood lipid level and delayed healing in patients with osteoporotic vertebral compression fractures after vertebroplasty.Methods:In a prospective study,140 patients with osteoporotic vertebral compression fractures admitted to the Department of Orthopedics of the Second Hospital of Traditional Chinese Medicine of Kaifeng from August 2019 to December 2021 were enrolled.At the time of admission,the baseline data of all patients were collected through the baseline data questionnaire.After completing relevant examinations,all patients were treated with vertebroplasty.The fracture healing of the patients at 3 months after surgery was counted.The patients with delayed healing were included in the occurrence group,and the rest were included in the non occurrence group.The baseline data,amount of bone cement,mode of anesthesia,bone mineral density,postoperative visual analog scale(VAS)score,blood lipid level and other indicators of the two groups were compared to explore the relationship between blood lipid level and delayed healing in patients with osteoporotic vertebral compression fractures after vertebroplasty.Results Three months after operation,delayed union occurred in 11 of 140 patients with osteoporotic vertebral compression fractures,accounting for 7.86%.There was a statistical significant difference in total cholesterol(TC),triglyceride(TG)and low-density lipoprotein(LDL-C)in the non occurrence group(P<0.05).There was no statistical significant difference between the two groups in baseline data,bone mineral density,VAS score,anesthesia methods,etc.(P>0.05).The results showed that there was a positive correlation between the blood lipid level after operation and the delayed healing of patients with osteoporotic vertebral compression fractures(r>0,P<0.05).Logistic regression analysis showed that the increase of TG,TC and LDL-C was related to delayed healing after vertebroplasty in patients with osteoporotic vertebral compression fractures(OR>1,P<0.05).Conclusion The levels of blood lipid(TC,TG,LDL-C)in patients with osteoporotic vertebral compression fractures after vertebroplasty are related to delayed healing.