幽门螺杆菌的耐药性分析和应对策略

Antibiotic resistance analysis and coping strategies of helicobacter pylori

幽门螺杆菌(Helicobacter pylori,H.pylori)是一种革兰阴性菌,主要定植于胃和十二指肠,它可以引起胃部炎症、消化性溃疡和胃癌等消化道疾病,根除H.pylori可以有效阻止消化道疾病的发生和发展。抗生素是治疗H.pylori的主要药物之一,由于抗生素的长期应用,H.pylori对抗生素的耐药率逐年上升,降低了H.pylori的根除率,增加了再次治疗的难度及患者的经济负担。本文将从H.pylori耐药现状、耐药机制和治疗三个方面进行综述,为应对严峻的耐药形势提供参考。

Helicobacter pylori(H.pylori)is a Gram-negative bacterium that mainly colonizes the stomach and duodenum,and it can cause gastrointestinal diseases such as gastric inflammation,peptic ulcer and gastric cancer,and eradication of H.pylori can effectively stop the occurrence and development of gastrointestinal diseases.Antibiotics are one of the main drugs used to treat H.pylori.Due to the long-term application of antibiotics,the resistance rate of H.pylori to antibiotics increases year by year,which greatly reduces the eradication rate of H.pylori and increases the difficulty of re-treatment and the economic burden of patients.In this paper,we will review three aspects of H.pylori resistance status,resistance mechanism and treatment to provide reference for the progress of H.pylori resistance research and its treatment strategy.