穴位埋线对肝阳上亢证高血压患者CGRP、NPY的影响

Effect of Implanting Catgut in Acupoint on CGRP and NPY in Hypertensive Patients with Syndrome of Upper Hyperactivity of Liver Yang

目的:探讨穴位埋线对肝阳上亢证高血压患者的效果及对降钙素基因相关肽(CGRP)、神经肽Y(NPY)的影响。方法:选择阳江市人民医院2021年1月—2022年6月收治的肝阳上亢证高血压患者80例,采用随机数字表法将筛选后的受试者按1∶1分配入对照组与观察组。对照组给予苯磺酸氨氯地平片+调整生活方式干预,观察组在对照组基础上给予穴位埋线干预。比较两组治疗前后血压、中医症候评分、血清CGRP及NPY水平,评价两组治疗安全性。结果:治疗前两组血压水平比较,差异均无统计学意义(P>0.05);治疗后两组收缩压、舒张压水平均低于治疗前,观察组均低于对照组(P<0.05)。治疗前两组中医症候评分比较,差异无统计学意义(P>0.05);治疗后两组中医症候评分均低于治疗前,观察组低于对照组(P<0.05)。治疗前两组血清CGRP、NPY水平比较,差异均无统计学意义(P>0.05);治疗后两组血清CGRP水平均高于治疗前,NPY水平均低于治疗前,观察组血清CGRP水平高于对照组,NPY水平低于对照组(P<0.05)。两组治疗过程中均未发生明显不良反应。结论:穴位埋线治疗肝阳上亢证高血压患者的效果良好,能够显著改善患者血压水平、临床症状,其作用机制可能与调控血清CGRP、NPY水平相关。

Objective:To investigate the effect of implanting catgut in acupoint on hypertensive patients with syndrome of upper hyperactivity of liver Yang and its influence on calcitonin gene-related peptide(CGRP)and neuropeptide Y(NPY).Method:A total of 80 hypertensive patients with syndrome of upper hyperactivity of liver Yang admitted to People's Hospital of Yangjiang from January 2021 to June 2022 were selected,and the selected subjects were allocated 1∶1 into the control group and the observation group by random number table method.The control group was given Amlodipine Besylate Tablets+lifestyle adjustment intervention,and the observation group was given implanting catgut in acupoint intervention on the basis of the control group.Blood pressure,TCM symptom score,serum CGRP and NPY levels before and after treatment were compared between the two groups,and the safety of treatment of the two groups were evaluated.Result:There were no significant differences in blood pressure levels between the two groups before treatment(P>0.05).After treatment,the levels of systolic blood pressure and diastolic blood pressure in both groups were lower than those before treatment,and those in observation group were lower than those in control group(P<0.05).Before treatment,there was no significant difference in TCM symptom score between the two groups(P>0.05).After treatment,the scores of TCM syndrome of the two groups were lower than those before treatment,and that of the observation group was lower than that of the control group(P<0.05).There were no significant differences in serum CGRP and NPY levels between the two groups before treatment(P>0.05).After treatment,the serum CGRP levels in both groups were higher than those before treatment,the serum NPY levels in both groups were lower than those before treatment,and the serum CGRP level in observation group was higher than that in control group,and the serum NPY level in observation group was lower than that in control group(P<0.05).There were no obvious adverse reactions during treatment in both groups.Conclusion:Implanting catgut in acupoint has a good effect in the treatment of hypertensive patients with syndrome of upper hyperactivity of liver Yang,and can significantly improve the blood pressure levels and clinical symptoms of patients,and its mechanism may be related to the regulation of serum CGRP and NPY levels.