内质网应激在巩膜重塑中的研究现状及进展

Research status and progress of endoplasmic reticulum stress in scleral remodeling

近视的发生发展与巩膜重塑密切相关。因此,为了有效防治近视,阐明巩膜重塑的发生机制至关重要。近年来,我国学者发现内质网应激可以通过未折叠蛋白反应中的肌醇需求蛋白-1/X盒结合蛋白-1通路调节凋亡蛋白的表达,从而参与调节缺氧状态下巩膜成纤维细胞的状态调节巩膜重塑的发生发展。与此同时,部分研究发现,通过药物及遗传学方法同时敲除内质网应激中的蛋白激酶RNA样内质网激酶和转录激活因子6,可以有效抑制眼轴的增长。这证明了内质网应激在巩膜重塑的发生发展过程中起到了重要作用。但对于内质网应激与巩膜重塑的综合分析国内外尚无报道。深入分析内质网与巩膜重塑的关联,对后续巩膜重塑机制的分析研究具有重要意义。

The occurrence and development of myopia is closely related to scleral remodeling.Therefore,in order to effectively prevent and cure myopia,it is very important to clarify the mechanism of scleral remodeling.In recent years,Chinese scholars have found that endoplasmic reticulum stress can regulate the expression of apoptotic proteins through the inositol demand protein-1/X box binding protein-1 pathway in the unfolded protein response,thus it is involved in regulating the state of scleral fibroblasts under hypoxia and regulating the occurrence and development of scleral remodeling.At the same time,some studies have found that inhibiting and knocking out protein kinase RNA-like endoplasmic reticulum kinase and activated transcription factor 6 in endoplasmic reticulum stress can effectively inhibit the growth of ocular axis.This proves that endoplasmic reticulum stress plays an important role in the occurrence and development of scleral remodeling.However,the comprehensive analysis of endoplasmic reticulum stress and scleral remodeling has not been reported at home and abroad.In-depth analysis of the relationship between endoplasmic reticulum and scleral remodeling is of great significance for the follow-up analysis and study of the mechanism of scleral remodeling.