银杏内酯注射液联合阿替普酶治疗急性脑梗死的临床效果

Clinical effect of ginkgolide injection combined with alteplase in the treatment of acute cerebral infarction

目的探讨银杏内酯注射液联合阿替普酶治疗急性脑梗死的效果。方法选取2020年1月至2021年12月我院收治的100例急性脑梗死患者作为研究对象,按照随机数字表法将其分为对照组和观察组,各50例。对照组采用常规治疗加阿替普酶静脉溶栓治疗,观察组在对照组的基础上加银杏内酯注射液静滴。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗7、14 d后,观察组的美国国立卫生研究院卒中量表(NIHSS)评分低于对照组(P<0.05)。治疗14 d后,观察组的白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。治疗14 d后,观察组的双侧大脑中动脉平均血流速度(Vm)和平均血流峰值流速(Vp)高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论银杏内酯注射液联合阿替普酶治疗急性脑梗死有利于缓解机体的炎症反应,改善脑血流灌注,恢复神经功能。

Objective To explore the effect of ginkgolide injection combined with alteplase in the treatment of acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted in our hospital from January 2020 to December 2021 were selected as the study objects.According to the random number table method,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with conventional therapy and alteplase intravenous thrombolysis,and the observation group was treated with ginkgolide injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After 7 and 14 d of treatment,the National Institute of Health Stroke Scale(NIHSS)score of the observation group was lower than that of the control group(P<0.05).After 14 d of treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).After 14 d of treatment,the mean blood velocity(Vm)and mean blood flow peak velocity(Vp)of the bilateral middle cerebral artery in the observation group were higher than those of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgolide injection combined with alteplase in the treatment of acute cerebral infarction is beneficial to alleviate the inflammatory response of the body,improve cerebral blood flow perfusion,and restore neurological function.