肺泡巨噬细胞免疫代谢与慢性阻塞性肺疾病关系的研究进展

Advances in studies on alveolar macrophage immunometabolism and chronic obstructive pulmonary disease

肺泡巨噬细胞(AMs)在慢性阻塞性肺疾病(COPD)的发病中起着重要作用,代谢途径和代谢产物的改变是AMs功能和相关疾病进展的关键因素之一。本文就影响AMs代谢变化的因素,以及代谢变化如何影响AMs的功能作了阐述,并进一步总结了AMs的免疫代谢变化在COPD中的研究进展,以期为COPD的防治提供新的思路和途径。

Alveolar macrophages(AMs)play critical roles in the pathogenesis of chronic obstructive pulmonary disease(COPD).Altered metabolism is the crucial factor that determines the function of AMs and disease progression.This paper expounds what factors affect the metabolic changes of AMs as well as how these metabolic changes alter the function of AMs,and further summarizes the research progress on immunometabolism of AMs in COPD,in order to explore new ideas and approaches in the prevention and treatment of COPD.