利那洛肽联合复方聚乙二醇电解质散在结肠镜检查肠道准备中的应用效果

Application effect of Linaclotide combined with PEG electrolyte powder in bowel preparation during colonoscopy

目的观察复方聚乙二醇(PEG)电解质散联合利那洛肽行肠道准备,在结肠镜检查中的效果和安全性。方法选取2022年3月1日-2022年8月30日该院收治的拟进行结肠镜检查的75例患者作为研究对象,采用随机数表法,将75例患者随机分为观察组、对照组A和对照组B,每组各25例。对照组A单用2 L复方PEG电解质散行肠道准备,对照组B单用3 L复方PEG电解质散行肠道准备,观察组采用利那洛肽联合2 L复方PEG电解质散行肠道准备。使用波士顿肠道准备评估量表(BBPS)评估患者肠道清洁度情况,统计患者满意度、不良反应发生率和肠道息肉检出率。结果观察组的肠道准备效果优于对照组A,息肉检出率高于对照组A;观察组患者满意率高于对照组B,不良反应总发生率低于对照组B,差异均有统计学意义(P<0.05)。结论利那洛肽联合2 L复方PEG电解质散的方案,可提高BBPS、息肉检出率和患者满意度,降低肠道准备过程中不良反应发生率,值得临床应用。

Objective To systematically observe the effect and safety of bowel preparation with compound polyethylene glycol(PEG)electrolyte powder and Linaclotide in bowel preparation for colonoscopy in patients.Methods 75 patients from March 1.2022 to August 30.2022 were enrolled as the study subjects.They were randomly divided into observation group,control group A and control group B,25 patients in each group by the method of random number table.The control group A was prepared with 2 L compound PEG electrolyte powder alone and the control group B with 3 L compound PEG electrolyte powder alone;The patients in the observation group were treated with Linaclotide with 2 L compound PEG electrolyte powder for intestinal preparation.Intestinal cleanliness was assessed using the Boston bowel preparation scale(BBPS),the patients’satisfaction,the incidence of adverse reactions and the detection rate of polyps were analyzed.Results The intestinal preparation effect of the observation group was better than that of the control group A,and the detection rate of polyps was higher than that of the control A.The satisfaction rate of patients in observation group was higher than that in the control group B,and the overall incidence of adverse reactions was lower than that in the control group B.Conclusion The regimen of Linaclotide combined with 2 L PEG electrolyte powder can improve BBPS,detection rate of polyps and patient satisfaction,reduce the incidence of adverse reactions during bowel preparation,be worthy of clinical application.