天然药食单体防治酒精性肝损伤的研究进展

Research advances in natural drug and food monomers in prevention and treatment of alcoholic liver injury

大量数据显示,酒精性肝损伤(ALI)的患病率呈逐年攀升趋势,且成为肝硬化、肝癌等慢性肝病致死的主要原因之一。现代医学对于ALI的预防主要是通过戒酒,治疗主要是采用具有抗氧化、抗纤维化作用的西药以及后期的营养支持。但西药的整体治疗效果并不理想,仅可缓解初期症状,若ALI较为严重,仍需采取手术治疗。研究表明,从天然药物、食物中提取的单体成分对ALI具有明显的防治作用,且安全性高、获取便利。因此,本文系统地概述了防治ALI的主要天然药食单体,并提出药食联用防治ALI的构想。从关注健康全过程的角度出发,以期探求更为有效的预防、保健及治疗方法,为ALI的防控提供研究思路。

A large number of data show that the prevalence rate of alcoholic liver injury(ALI)is increasing year by year,and it has become one of the main causes of death due to chronic liver diseases such as liver cancer and liver cirrhosis.Quitting drinking is the main method for the prevention of ALI in modern medicine,and the main treatment methods include Western medicine with antioxidant and anti-fibrotic effects and nutritional support.However,Western medicine tends to have an unsatisfactory treatment effect and can only alleviate initial symptoms,and severe ALI still requires surgical treatment.Studies have shown that the monomers extracted from natural drugs and foods have obvious preventive and therapeutic effects on ALI,with high safety and easy access.Therefore,this article systematically summarizes the main natural drug and food monomers used for the prevention and treatment of ALI and proposes the idea of the combination of drug and food for the prevention and treatment of ALI from the perspective of paying attention to the whole process of health,in order to explore more effective prevention,health care,and treatment methods and provide ideas for research on the prevention and control of ALI.