胰高血糖素样肽-2与肠道损伤的关系及相关机制的研究进展

Research progress in the relationship between glucagon-like peptide-2 and intestinal injury and related mechanisms

胰高血糖素样肽-2(GLP-2)是一种具有肠道保护作用的特异性生长因子, 通过多种下游信号通路发挥对肠道损伤后的再生修复作用, 主要体现在保证肠道结构的完整性, 增强肠道屏障的功能, 增加肠道的血液供应, 以及促进营养物质的吸收。因此, 其在肠道损伤的临床应用中也越来越普遍。本文将概括总结GLP-2的特性、与肠道损伤的关系、作用机制和临床应用等方面的最新研究进展。

Glucagon-like peptide-2(GLP-2)is a specific growth factor with intestinal protective effect.It plays a role in the regeneration and repair of intestinal injury through a variety of downstream signal pathways,which is mainly reflected in ensuring the integrity of intestinal structure,enhancing the function of intestinal barrier,increasing the blood supply of intestinal tract,and promoting the absorption of nutrients.Therefore,it is more and more popular in the clinical application of intestinal injury.This paper will summarize the latest research progress in the characteristics of GLP-2,its relationship with intestinal injury,mechanism of action and clinical application.