左旋多巴联合遮盖疗法治疗儿童弱视的临床疗效

Clinical Effects of Levodopa Combined with Occlusion Therapy in the Treatment of Amblyopia in Children

目的:观察左旋多巴联合遮盖疗法治疗儿童弱视的临床疗效.方法:选择2021年3月至2022年3月开封市中心医院收治的132例弱视患儿为研究对象,依据治疗方案分成实验组(n=68,采用左旋多巴联合遮盖疗法治疗)和对照组(n=64,采用遮盖疗法治疗),对比两组治疗效果.结果:治疗后,实验组的最佳矫正视力(BCVA)高于对照组,差异有统计学意义(P<0.05),潜时降低程度与振幅升高幅度大于对照组,差异有统计学意义(P<0.05),矫正近立体视锐度小于对照组,其矫正辐辏范围、矫正分开范围大于对照组,差异有统计学意义(P<0.05),总有效率高于对照组,差异有统计学意义(P<0.05).两组并发症发生率比较无统计学意义,差异有统计学意义(P>0.05).结论:左旋多巴联合遮盖疗法治疗对儿童弱视有明显的临床疗效,且安全性较高.

Objective:To observe the clinical effects of levodopa combined with occlusion therapy in the treatment of children with amblyopia.Methods:A total of 132 children with amblyopia admitted to our hospital from March 2021 to March 2022 were selected.According to the therapeutic method,they were divided into experimental group(n=68,levodopa combined with occlusion therapy)and control group(n=64,occlusion therapy).Compare treatment effects between the two groups.Results:After treatment,the best corrected visual acuity(BCVA)of the experimental group was higher than that of the control group(P<0.05);the degree of latent time reduction and amplitude increase in the experimental group were greater than those in the control group(P<0.05),the corrected near-stereoscopic acuity of the experimental group was less than that of the control group,and the corected amplitude range and corrected separation range of the experimental group were greater than those of the control group(P<0.05),the total effective rate of experimental group was higher than that of control group(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Levodopa combined with occlusion therapy has obvious clinical efficacy and high safety in the treatment of amblyopia in children.