左氧氟沙星联合常规疗法治疗老年慢性阻塞性肺疾病合并肺结核的效果

Effect of Levofloxacin Combined with Conventional Therapy in Treatment of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Tuberculosis in Elderly

目的:探究左氧氟沙星联合常规疗法治疗老年慢性阻塞性肺疾病合并肺结核患者的临床效果。方法:选取2021年1月—2022年12月宁夏回族自治区第四人民医院收治的老年慢性阻塞性肺疾病合并肺结核患者92例作为研究对象,随机分为两组,各46例。对照组开展常规治疗,试验组在对照组基础上给予左氧氟沙星胶囊治疗。比较两组治疗效果。结果:试验组痰菌转阴率、双肺阴影消失率、空洞改善率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组第1秒用力呼气容积、用力肺活量、深吸气量高于对照组,残气量、肺总量低于对照组,差异有统计学意义(P<0.001)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.014)。结论:左氧氟沙星联合常规疗法治疗老年慢性阻塞性肺疾病合并肺结核的效果显著,可改善临床症状,提高肺功能。

Objective:To explore the clinical effect of levofloxacin combined with conventional therapy in treatment of elderly patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis.Methods:A total of 92 elderly patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis admitted to the Fourth People's Hospital of Ningxia Hui Autonomous Region from January 2021 to December 2022 were selected as the study subjects and randomly divided into two groups,with 46 cases in each group.The control group received conventional treatment,and the experimental group received levofloxacin capsules on the basis of the control group.The therapeutic effect of the two groups was compared.Results:The sputum negative conversion rate,double lung shadow disappearance rate and cavity improvement rate in experimental group were higher than those in control group,and the differences were statistically significant(P<0.05).After treatment,forced expiratory volume in 1 second,forced vital capacity,and inspiratory capacity in experimental group were higher than those in control group,residual volume and total lung capacity in experimental group were lower than those in control group,and the difference was statistically significant(P<0.001).The total effective rate of treatment in experimental group was higher than that in control group,and the difference was statistically significant(P=0.014).Conclusion:Levofloxacin combined with conventional therapy is effective in the treatment of chronic obstructive pulmonary disease complicated with pulmonary tuberculosis in the elderly,which can improve clinical symptoms and lung function.