衰老机制和衰老干预研究的近期进展和前景展望

Recent progress and future prospects on mechanisms and interventions of aging

健康寿命的调控机制逐渐成为衰老研究领域内最前沿的方向之一。近年来,一些新思路、新方法的出现为健康寿命调控机制研究注入了新的活力。比如,利用异种共生的方法阐明了循环系统如何影响衰老进程,为干预衰老提供了新思路;单细胞测序分析技术使科学家们能够从单细胞水平上解析组织器官、机体的衰老进程中基因表达的时空变化规律;多组学生物信息学分析技术助力了在长寿人群中发现与健康长寿相关的遗传元件、环境因素。这些新技术的运用为衰老研究带来了新的机遇。

The mechanism of health span regulation has gradually become one of the most advanced directions in the field of aging research.Recently,the emergence of new strategies and technologies has provided completely new insights into the molecular mechanism of health span.For example,the use of parabiosis methods has demonstrated how the circulatory system affects the aging process,providing new ideas for aging interventions;single-cell sequencing analysis technology enables scientists to analyze the temporal and spatial changes of gene expression in tissues,organs and organisms during aging at the single cell level;multi-omic bioinformatics analysis technology has assisted in discovering genetic elements and environmental factors related to health and longevity in the long-lived population.The application of these new technologies has brought new opportunities for aging research.