金银花源miR2911靶向非洲猪瘟病毒基因区域分析

Analysis of Honeysuckle miR2911 Targeting Gene Regions of ASFV

金银花源miR2911是一种高丰度、性质稳定的抗病毒分子,在抗流感病毒感染、SARS-CoV-2感染中具有一定效果。然而,对于miR2911靶向ASFV基因区域的研究却鲜有报道。由此,本研究旨在分析miR2911靶向ASFV的基因区域,从而进一步分析miR2911靶点在不同流行毒株中的保守性。利用miRanda软件成功预测了miR2911在ASFV基因组中存在的多个靶点,且靶向ASFV基因区域保守性很高。为后续深入研究miR2911在抗猪源病毒感染机理方面提供理论依据。

Honeysuckle source miR2911 was a highly abundant and stable antiviral assay that played a key role in fighting against influenza virus and SARS-CoV-2 infection.However,studies on miR2911 targeting gene regions of ASFV have rarely been reported.In this study,we aimed to analyze the gene regions of miR2911 targeting ASFV,and make a further analysis of the conservation of miR2911 targets in different epidemic strains.The miRanda software was used to successfully predict the presence of multiple targets of miR2911 in the genomes of ASFV.The results showed that the gene regions targeting ASFV were highly conserved.It provided important supporting data for the subsequent in-depth study of the mechanism of miR2911 in the anti-swine virus infection.