1990-2019年我国归因于吸烟的喉癌疾病负担变化趋势分析

Change trend analysis of disease burden in laryngeal cancer attributable to smoking in China from 1990 to 2019

目的探讨1990-2019年我国归因于吸烟的喉癌疾病负担变化趋势。方法基于全球疾病负担研究2019数据库数据,分析1990-2019年我国不同性别、年龄人群因吸烟导致喉癌死亡例数、死亡率、伤残调整寿命年(DALY)以及DALY率变化情况。采用Joinpoint软件估计归因死亡率和DALY率的年度变化百分比(APC)和平均年度变化百分比(AAPC),分析归因于吸烟的喉癌死亡和DALY的变化趋势。结果我国1990-2019年归因于吸烟的喉癌死亡率和DALY率整体呈上升趋势(死亡率AAPC为1.6%,P<0.05;DALY率AAPC为1.26%,P<0.05)。2019年我国75.64%的喉癌死亡归因于吸烟,归因死亡例数和死亡率分别为15336例和1.08/10万,归因DALY和DALY率分别为376143人年和26.45/10万。男性归因于吸烟的喉癌人群归因分值、死亡例数、死亡率、DALY和DALY率均高于女性。我国归因于吸烟的喉癌死亡人数和DALY在50~69岁年龄组达到高峰,归因死亡率和DALY率在≥70岁年龄组达到高峰。结论1990-2019年我国归因于吸烟的喉癌疾病负担沉重,且存在性别和年龄差异。

ObjectiveTo explore the change trend of disease burden in laryngeal cancer attributable to smoking in China from 1990 to 2019.MethodsBased on data from the 2019 Global Burden of Disease Study database,the changes of death cases,mortality,disability adjusted life years(DALY)and DALY rate of laryngeal cancer attributable to smoking among people with different gender and age in China from 1990 to 2019 were analyzed.Joinpoint software was used to evaluate the annual percentage change(APC)and average annual percentage change(AAPC)of attributable mortality and DALY rate.The change trend of laryngeal cancer death attributable to smoking and DALY was analyzed.ResultsFrom 1990 to 2019,the mortality rate and DALY rate of laryngeal cancer attributable to smoking in China showed an overall upward trend(AAPC of mortality was 1.6%,P<0.05;AAPC of DALY rate was 1.26%,P<0.05).In 2019,75.64%of laryngeal cancer deaths in China were attributable to smoking,with 15336 attributable deaths,1.08/100000 attributable mortality rates,376143 person-year attributable DALY and 26.45/100000 attributable DALY rates,respectively.The population attributable fraction,death number,mortality rate,DALY and DALY rate of laryngeal cancer attributable to smoking in males were higher than those in females.In China,the number of laryngeal cancer deaths and DALY attributable to smoking peaked in the age group of 50-69 years old,and the attributable mortality and DALY rate peaked in the age group of≥70 years old.ConclusionsThe disease burden of laryngeal cancer attributable to smoking is high in China from 1990 to 2019,and there are differences in gender and age.