超声靶向微泡破坏技术在脑胶质瘤治疗中的应用进展

Application progress of ultrasound-targeted microbubble destruction technology in glioma treatment

脑胶质瘤(glioma)是成人中枢神经系统最常见的原发性颅内恶性肿瘤,由于脑胶质瘤浸润生长的特性,单纯手术难以完全切除。目前主流治疗方案是手术切除联合放射治疗、化学治疗或生物治疗。由于血脑屏障、血瘤屏障及酶屏障等多重因素的存在,药物很难达到或渗透肿瘤,患者5年生存率鲜有明显改善。超声靶向微泡破坏技术通过超声空化效应能够可逆地开放生物屏障,促进靶向药物、基因治疗载体以及化学治疗药物的吸收,在脑胶质瘤治疗中具有重大意义。

Glioma is the most common primary intracranial malignant tumor in adult popularity.Due to the infiltrating characteristics,glioma can hardly be cleaned via surgical techniques alone.At present,the mainstream treatment is surgical resection combined with radiotherapy,chemotherapy or biological therapy.Nevertheless,multiple factors such as blood-brain barrier,tumor blood-brain barrier and enzyme barrier resist drugs reaching or penetrating tumor.Therefore,the 5-year survival rate of patients has rarely been significantly improved.Ultrasound targeted microbubble destruction technology can reversibly open the blood-brain barrier through ultrasonic cavitation effect,and promote the absorption of targeted drugs,gene therapy veihchel as well as the chemotherapy drug,which is of great significance in the treatment of glioma.