多黏菌素耐药mcr基因的研究进展

Advances in research on polymyxin resistance mcr gene

多黏菌素是治疗多重耐药革兰氏阴性菌感染的“最后一道防线”,然而质粒介导的多黏菌素抗性基因mcr-1及其变异体在全球传播,给畜牧业健康发展和人类公共卫生安全带来了严重挑战。文章综述了mcr-1基因的发现、结构和流行情况,mcr-1基因变异体、流行特征以及防治策略等的研究进展,以期为相关科研人员和临床工作者提供参考,共同应对抗生素耐药日益严峻的局面。

Polycolistin is the‘last line of defense’against multi-drug-resistant gram-negative infections.However,the global spread of plasmid-mediated polycolistin resistance gene mcr-1 and its variants has brought serious challenges to the healthy development of animal husbandry and human public health security.In this paper,the discovery,structure and prevalence of mcr-1 gene,mcr-1 gene variants,their epidemic characteristics and prevention strategies were reviewed,in order to provide reference for relevant researchers and clinical workers to jointly deal with the increasingly severe situation of antibiotic resistance.