摘要
多黏菌素是治疗多重耐药革兰氏阴性菌感染的“最后一道防线”,然而质粒介导的多黏菌素抗性基因mcr-1及其变异体在全球传播,给畜牧业健康发展和人类公共卫生安全带来了严重挑战。文章综述了mcr-1基因的发现、结构和流行情况,mcr-1基因变异体、流行特征以及防治策略等的研究进展,以期为相关科研人员和临床工作者提供参考,共同应对抗生素耐药日益严峻的局面。
Polycolistin is the‘last line of defense’against multi-drug-resistant gram-negative infections.However,the global spread of plasmid-mediated polycolistin resistance gene mcr-1 and its variants has brought serious challenges to the healthy development of animal husbandry and human public health security.In this paper,the discovery,structure and prevalence of mcr-1 gene,mcr-1 gene variants,their epidemic characteristics and prevention strategies were reviewed,in order to provide reference for relevant researchers and clinical workers to jointly deal with the increasingly severe situation of antibiotic resistance.
作者
曹兴旺
李益涛
徐道元
付祥益宁
何欣
陈扬
田美卉
王超丽
霍明凯
肖陈城
李亚玲
CAO Xingwang;LI Yitao;XU Daoyuan;FU Xiangyining;HE Xin;CHEN Yang;TIAN Meihui;WANG Chaoli;HUO Mingkai;XIAO Chencheng;LI Yaling(College of Animal Science and Technology,Shihezi University,Shihezi 832000,China;Shihezi Veterinary Association,Shihezi 832000,China)
出处
《黑龙江畜牧兽医》
北大核心
2023年第19期29-36,共8页
Heilongjiang Animal Science And veterinary Medicine
基金
第七师-石河子大学科技创新专项
石河子大学青年创新人才计划项目(CXBJ202202)
广东省科技计划项目(2021B1212030015)。