基于聚己内酯微球的胶原刺激填充剂的基础及临床研究进展

The Fundamental and Clinical Research Progress on Polycaprolactone(PCL)-Based Collagen-Stimulator

近年来,随着注射微整形需求量的增加,填充剂的类型也不断出现。一种基于聚己内酯微球(Polycaprolactone,PCL)的填充剂伊妍仕(Ellansé®)刚刚获批进入中国市场,是新一代的胶原刺激剂,具有即刻填充、刺激自身胶原新生的作用。本文综述了基于PCL的填充剂的结构、生物降解途径和生物安全性,并对其基础研究和临床应用进行了详细的描述,以期为临床医生的使用提供参考。

In recent years,as the demand for injection microplastic surgery has increased,types offillers have also continued to appear.Ellansé,afiller based on polycaprolactone(PCL)microspheres,has just been approved to enter the Chinese market.It is a new generation of collagen stimulant that can instantlyfill and stimulate its own collagen regeneration.This article reviews the structure,biodegradation pathways and biosafety of PCL-based fillers,and provides a detailed description of its basic research and clinical applications in order to provide references for clinicians'use.