摘要
建立了阿瑞匹坦结构的研究方法。分别开展了阿瑞匹坦结构研究。结果表明,阿瑞匹坦结构的红外吸收模式主要包括:C=O结构伸缩振动模式(ν(C=O-阿瑞匹坦))、C=C结构伸缩振动模式(ν_(C=O-阿瑞匹坦))、CF3结构不对称伸缩振动模式(ν_(asCF3(-阿瑞匹坦)))、C-F结构伸缩振动模式(ν_(C-F阿瑞匹坦))和C-O结构伸缩振动模式(ν_(C-O-阿瑞匹坦))。阿瑞匹坦结构去卷积MIR光谱的谱图分辨能力要优于相应的一维MIR光谱、二阶导数MIR光谱、四阶导数MIR光谱,并能提供更加丰富的光谱系信息。
A research method for the structure of aprepitant was established.The aprepitant structure were characterized by the mi-infrared(MIR)spectroscopy.The test found that the infrared absorption mode of aprepitant included C=O structure stretching vibration mode(ν_(C=0_(Arepitan)),C=C structural stretching vibration mode(ν_(C=C_(Arepitan)),CF3 structures asymmetric stretching vibration mode(ν_(asCF_(3)_(Arepitan))),C-F structure stretching vibration mode(ν_(C=F_(Arepitan))and C-O structure stretching vibration mode(ν_(C=O_(Arepitan)).It has found that the spectral resolution of the deconvolution MIR spectra of the Arepitan structure is superior to the corresponding one-dimensional MIR spectra,second-order derivative MIR spectra,and fourth-order derivative MIR spectra,and can provide richer spectral information.
作者
王春润
雷晓静
周子轩
常美玲
于宏伟
张勇
常明
王丽欣
Wang Chunrun;Lei Xiaojing;Zhou Zixuan;Chang Meiling;Yu Hongwei;Zhang Yong;Chang Ming;Wang Lixin(Hebei University of Science&Technology School of Chemical and Pharmaceutical Engineering,Shijiazhuang 050018,China;Shijiazhuang University College of Chemical Engineering,Shijiazhuang 050035,China;Anesthetic Technology Innovation Center of Hebei Province,Shijiazhuang 050035,China)
出处
《煤炭与化工》
CAS
2023年第9期138-143,160,共7页
Coal and Chemical Industry
基金
河北科技大学大学生创新创业孵化项目(2023A015)
石家庄市麻醉药技术创新中心项目(2023)
河北省生物制药国际联合中心项目(2023)。
关键词
阿瑞匹坦
结构
一维中红外光谱
二阶导数中红外光谱
四阶导数中红外光谱
去卷积中红外光谱
aprepitant
structure
one-dimensional mid infrared spectroscopy
second-order derivative mid infrared spectroscopy
fourth-order derivative mid infrared spectroscopy
deconvolved mid infrared spectroscopy
