慢性咽喉疾病与幽门螺杆菌感染相关性研究

Investigation on the correlation between chronic throat diseases and Helicobacter pylori infection

目的调查研究慢性咽炎患者和反流性咽喉炎患者的幽门螺杆菌感染情况。方法随机选取2019年1月~2021年10月来我院就诊的慢性咽喉炎性疾病患者250例,并随机选取同期体检中心健康体检者200例作为对照组,采用免疫印迹法检测所有受试者是否感染幽门螺杆菌以及具体感染类型,并做统计学比较。结果反流性咽喉炎组和慢性咽炎组幽门螺杆菌阳性率均明显高于对照组,差异有统计学意义。反流性咽喉炎组女性感染率明显高于慢性咽炎组,差异有统计学意义。反流性咽喉炎组I性抗体阳性率明显高于慢性咽炎组,且反流性咽喉炎组和慢性咽炎组的幽门螺杆菌I型和II型抗体表达明显高于对照组的I型和II型抗体表达。结论反流性咽喉炎组和慢性咽炎组幽门螺杆菌普遍易感。反流性咽喉炎幽门螺杆菌检出率明显高于慢性咽炎组,且反流性咽喉炎HP-I型抗体(VacA/CagA毒素蛋白)检出率明显高于HP-II型抗体,提示表达I型抗体幽门螺杆菌在反流性咽喉炎的进展中发挥重要影响。

Objective To investigate Helicobacter pylori infection in patients with chronic pharyngitis and reflux pharyngitis.Methods A total of 250 patients with chronic pharyngitis in our hospital from January 2019 to October 2021 were randomly selected,and 200 healthy subjects in physical examination center during the same period were randomly selected as the control group.Western blotting was used to detect whether all subjects were infected with helicobacter pylori and the specific types of infection,and statistical comparison was made.Results The positive rate of Helicobacter pylori in reflux pharyngitis group and chronic pharyngitis group was significantly higher than that in control group,and the difference was statistically significant.The infection rate of women in the reflux pharyngitis group was significantly higher than that in the chronic pharyngitis group,and the difference was statistically significant.The positive rate of antibody I in the reflux pharyngitis group was significantly higher than that in the chronic pharyngitis group,and the expression of Helicobacter pylori type I and II antibody in the reflux pharyngitis and chronic pharyngitis groups was significantly higher than that in the control group.Conclusion Helicobacter pylori is generally susceptible in all groups(the reflux pharyngitis and the chronic pharyngitis group).The infection rate of Helicobacter pylori in reflux pharyngitis was higher than that in the chronic pharyngitis,and the positive rate of Helicobacter pylori type I antibody(VacA/CagA toxin protein)expression in the reflux pharyngitis group was significantly higher than that other two groups,suggesting that Helicobacter pylori infection is significantly affected by reflux pharyngitis,and Helicobacter pylori infection is involved in the occurrence and development of this disease.