再生性牙髓治疗在成人根尖发育不全恒牙应用的研究进展

Regenerative endodontic procedures for permanent tooth with immature apices in adult patients

再生性牙髓治疗运用组织工程学原理,旨在实现牙根继续发育和牙髓牙本质复合体的功能性再生,已成为牙髓坏死年轻恒牙的首选治疗方案。成人根尖发育不全的感染恒牙的治疗难点在于形成根尖三维封闭和增强牙根抗折性。随着组织工程和生物材料的发展,再生性牙髓治疗在成人恒牙中的运用值得关注和探索。本文对再生性牙髓治疗应用于成人根尖发育不全恒牙的生物学基础、临床进展、治疗难点与策略进行了梳理、分析和阐述,并对其临床应用前景进行讨论。

Regenerative endodontic procedures have been used to treat infected immature permanent teeth in children and adolescents to achieve continued root development and dentin-pulp complex formation.Treating the infected teeth of adult patients with immature apices is challenging.Current treatments form physical barriers by apexification or apical barrier technique.Although teeth can be saved,they are devitalized and become susceptible to reinfections and fractures.With the development of tissue engineering and biomaterials,researchers have tried to save the immature permanent teeth of adults by regeneration.Here,the clinical efficacy of regenerative endodontic procedures is analyzed to explore whether they should be developed for dental pulp and/or dentin regeneration in adults with immature apices.