聚苯乙烯基磁性纳米塑料磁共振成像效果分析

Magnetic resonance imaging effect of polystyrene-based magnetic nanoplastics

为了用于高效的细胞磁共振成像(MRI),开发了基于聚苯乙烯/Fe_(3)O_(4)纳米粒子的T2加权造影剂.采用双细乳液聚合法和分散聚合法分别制备出两种不同尺寸的纳米塑料模型,并对其进行细胞磁共振成像.结果表明:随着纳米塑料模型暴露浓度的增加,标记的小鼠巨噬细胞伪彩图像显示出显著的负对比度增强,灰度图像暗度加强,MRI信号强度也随着浓度的增加逐渐降低.ICP分析结果证实了小鼠巨噬细胞摄取纳米塑料模型的量随着样品浓度的增加而增加,聚苯乙烯基磁性纳米塑料模型可以为纳米塑料的细胞MRI成像提供一个全新的视角.

For efficient cellular magnetic resonance imaging(MRI),a T2-weighted contrast agent based on polystyrene/Fe_(3)O_(4) nanoparticles was developed.Two kinds of nanoplastic models with different sizes were prepared by double miniemulsion polymerization and dispersion polymerization,respectively,and the cell MRI was performed on them.The results showed that:with the increase of the exposure concentration of the nano-plastic model,the pseudo-color images of labeled mouse macrophages showed significant negative contrast enhancement,enhanced darkness of the gray image,and a gradual decrease in the intensity of MRI signal.The results of the ICP analysis confirmed that the uptake of the nanoplastic model by mouse macrophages increased with the increase of sample concentration.The polystyrene magnetic nanoplastic model can provide a new perspective for the cell MRI imaging of nanoplastics.