中国中老年人群抑郁症状与代谢综合征的关联分析

The association between depressive symptoms and metabolic syndrome among the middle-aged and elderly populations in China

目的分析中国中老年人抑郁症状对代谢综合征(metabolic syndrome,MS)患病的影响。方法选取2015年中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据库中重要变量完整的6963名年龄≥45岁的中老年人为研究对象,采用简版流调中心抑郁水平评定量表(the center for epidemiological studies depression scale,CES-D10)评估抑郁症状,根据2020年中华医学会糖尿病学分会(Chinese Diabetes Society,CDS)提出的诊断标准评估MS的患病情况。采用倾向性评分匹配法,在均衡潜在混杂因素的基础上估计抑郁症状对中国中老年人MS患病的平均处理效应(average treatment effect on the treated,ATT),以探究抑郁症状对MS影响。结果6963例研究对象中,有33.10%(95%CI:32.00%~34.21%)的中老年人存在抑郁症状,MS检出率为18.44%(95%CI:17.53%~19.35%)。经倾向性评分均衡混杂因素后发现,抑郁症状对中老年人是否患MS没有影响(ATT=-0.002~0.002,均P>0.05)。结论中国中老年人群的抑郁症状和MS检出率较高,但有抑郁症状与该人群是否患MS无明显关联。

Objective The objective of the study was to analyze the impact of depressive symptoms on metabolic syndrome(MS)in middle-aged and older Chinese adults.Methods A total of 6963 people aged≥45 years with complete and important variables from the China Health and Retirement Longitudinal Survey(CHARLS)database in 2015 were extracted.Depressive symptoms were assessed using the center for epidemiological studies of depression(CES-D10)scale.MS was defined under the diagnostic criteria proposed by China Diabetes Society(CDS)in 2020.To analyze the association between depressive symptom and MS,propensity score matching was performed to control for potential bias,and the average treatment effect on the treated(ATT)between groups was estimated to verify the effect of depressive symptoms on MS.Results Among the 6963 subjects,33.10%(95%CI:32.00%-34.21%)of middle-aged and older adults had depressive symptoms,and the detection rate of MS was 18.44%(95%CI:17.53%-19.35%).After adjusting for potential confounders by propensity score matching,no significant association was observed between depressive symptoms and MS in middle-aged and older adults(ATT=-0.002-0.002,all P>0.05).Conclusions In the middle-aged and elderly population in China,both depressive symptoms and MS were detected at high rates,but having depressive symptoms was not significantly associated with the presence of MS in this population.