老年甲状腺疾病患者血清hs-CRP、25-(OH)VD及血脂水平与血糖控制不佳的关系

Relationship between serum hs-CRP,25-(OH)VD,lipid levels and poor glycemic control in elderly patients with thyroid disease

目的研究老年甲状腺疾病患者血清hs-CRP、25-(OH)VD及血脂水平与血糖控制不佳的关系。方法该研究采用前瞻性研究,主要以2018年1月-2020年12月收治的136例甲状腺疾病患者作为研究对象,另选取同期进行健康体检的健康人员136例作为对照组,比较两组的FT3、FT4、FSH、PTH、血脂、血糖、hs-CRP、25-(OH)VD水平之间的差异,分析FT3、FT4、FSH、PTH与血糖、血脂以及hs-CRP、25-(OH)VD水平的相关性。结果疾病组患者的FT3(t=97.497,P=0.000)、FT4(t=767.556,P=0.000)、FSH(t=69.189,P=0.000)、PTH(t=23.122,P=0.000)水平显著高于健康组;疾病组患者的TG(t=10.745,P=0.000)、TC(t=6.671,P=0.000)、LDL(t=19.014,P=0.000)显著高于健康组,HDL(t=74.088,P=0.000)显著低于健康组;疾病组患者的空腹血糖(t=8.698,P=0.000)、餐后2小时血糖(t=9.504,P=0.000)以及糖化血红蛋白(t=12.730,P=0.000)显著高于健康组;疾病组患者的hs-CRP(t=19.862,P=0.000)显著高于健康组,25-(OH)VD(t=6.278,P=0.000)显著低于健康组,通过相关性分析,患者的FT3、FT4、FSH、PTH水平与TG、TC、LDL、空腹血糖、餐后2小时血糖、糖化血红蛋白、hs-CRP水平呈现正相关,与HDL、25-(OH)VD呈现负相关。结论老年甲状腺疾病患者血清hs-CRP、25-(OH)VD及血脂水平与血糖呈现显著的相关性,未来在对甲状腺疾病的治疗中,建议重视血糖以及血脂水平的控制。

Objective To study the relationship between poor blood glucose control and serum hs-CRP,25-(OH)VD and blood lipid levels in elderly patients with thyroid disease.Methods In this prospective study,136 patients with thyroid diseases from January 2018 to December 2020 were selected as the research objects,and another 136 health personnel with health examination were selected as the control group.The differences of FT3,FT4,FSH,PTH,blood lipid,blood glucose,hs-CRP,25-(OH)VD levels between the two groups were compared,and the relationship between FT3,FT4,FSH,PTH and blood glucose,serum lipid,blood glucose were analyzed.The levels of serum lipids,hs-CRP and 25-(OH)VD were correlated.Result The levels of FT3(t=97.497,P=0.000),FT4(t=767.556,P=0.000),FSH(t=69.189,P=0.000)and PTH(t=23.122,P=0.000)in the disease group were significantly higher than those in the healthy group;TG(t=10.745,P=0.000),TC(t=6.671,P=0.000)and LDL(t=19.014,P=0.000)in the disease group were significantly higher than those in the healthy group,while HDL(t=74.088,P=0.000)in the disease group were significantly lower than those in the healthy group;the fasting blood glucose(t=8.698,P=0.000),postprandial blood glucose(t=9.504,P=0.000)and glycosylated hemoglobin(t=12.730,P=0.000)in the disease group were significantly higher than those in the healthy group;Hs-CRP(t=19.862,P=0.000)in the disease group was significantly higher than that in the healthy group,and 25-(OH)VD(t=6.278,P=0.000)was significantly lower than that in the healthy group.Through correlation analysis,the levels of FT3,FT4,FSH and PTH were positively correlated with TG,TC,LDL,fasting blood glucose,postprandial blood glucose,glycosylated hemoglobin and hs-CRP,and negatively correlated with HDL and 25-(OH)VD.Conclusion Serum hs-CRP,25-(OH)VD and blood lipid levels in elderly patients with thyroid disease were significantly correlated with blood glucose.In the future,it is suggested to pay attention to the control of blood glucose and blood lipid levels in the treatment of thyroid disease.