抗病毒抗体Fc效应功能研究进展

Research Progress on the Effector Function of Antiviral Antibody Fc

近年来,抗病毒抗体在治疗新型冠状病毒、人类免疫缺陷病毒、呼吸道合胞病毒等病毒感染时,展现出了良好的治疗效果和生物安全性。其不仅可以通过抗体Fab中和病毒阻止感染,还可以通过Fc结合效应细胞上的Fc受体发挥不同的效应功能清除病毒。本综述介绍了抗病毒抗体Fc介导的生物学效应,总结了其在抗病毒感染中的重要性,同时讨论了其可能引发的副作用。此外,本文对抗病毒抗体药物Fc片段选择及工程化改造进行了概述,以期为开发新型抗病毒抗体药物提供新的思路和参考。

In recent years,antiviral antibodies have shown good therapeutic effect and biological safety in the treatment of SARS-CoV-2,human immunodeficiency virus,respiratory syncytial virus and other viral infections.These antibodies not only neutralize the virus through the Fab domain to prevent infection,but also clear the virus through Fc domain binding to the Fc receptor on the effector cells to exert different effector functions.This review described the biological effects of Fc domain in antiviral antibodies,summarized its importance in antiviral infections,and discussed its possible side effects.In addition,this review summarized the research progress on Fc fragment selection and engineering to change the effect function of antiviral antibody,in order to provide new ideas and references for the development of new antiviral antibody drugs.