昆虫杆状病毒的核心基因研究进展

Research Progress on Core Genes of Insect Baculovirus

杆状病毒是一类具有双链、环状、超螺旋基因组的DNA病毒。在目前已经测序的杆状病毒中,存在一组高度保守的杆状病毒核心基因。这些核心基因所编码的蛋白,部分是病毒粒子的结构成分,参与核衣壳组装与转运、核酸合成和感染宿主中肠组织的重要过程。因此,对核心基因进行研究,有助于揭示杆状病毒的复制、转录以及入侵宿主的机制,并且对其他昆虫病毒的研究也具有重要的借鉴意义。基于38个核心基因的串联序列,本文对16种杆状病毒进行系统发育分析;围绕杆状病毒核心基因的功能、分类、进化以及核心基因在生活史中的扮演的角色进行了较为详尽的阐述,并对今后的研究工作进行了展望。

Baculovirus is a class of DNA viruses with a double-stranded, ring-shaped, superhelical genome.There are a set of highly conserved core genes among the baculoviruses that have been sequenced so far. Some of the proteins encoded by these core genes are the structural components of virions and are involved in the important processes of nucleocapsid assembly and transport, nucleic acid synthesis and infection of host midgut tissues. Therefore, the study of core genes is helpful to reveal the mechanisms of baculovirus replication, transcription, host invasion, and also provides important references for the study of other insect viruses. Based on the tandem sequences of 38 core genes, this paper presents a phylogenetic analysis of 16 baculovirus strains.The function, classification and evolution of baculovirus core genes as well as the role played by core genes in life cycle are described in detail and future research direction is envisioned.