老年肺癌患者继发侵袭性真菌感染的危险因素及预后分析

Analysis of risk factors and prognosis of secondary invasive fungal infections in elderly lung cancer patients

目的探讨老年肺癌患者继发侵袭性真菌感染(invasive fungal infections,IFI)的危险因素及预后。方法回顾性选取2020年6月—2021年6月于南通市第六人民医院收治的老年肺癌患者110例,根据其是否继发IFI分为继发组(n=48)和未继发组(n=62)。比较两组的一般资料,并采用二元Logistic回归分析法探讨老年肺癌患者继发IFI的相关因素,并对其预后进行分析。结果继发组营养状况差、吸烟、TNM分期ⅢⅣ期、放化疗、糖尿病、长期使用抗菌素占比均高于未继发组(P<0.05);而2组年龄、高血压、性别、病理类型占比差异均无统计学意义(P>0.05)。二元Logistic回归分析表明,营养状况差、放化疗、糖尿病、长期使用抗菌素是老年肺癌患者继发IFI的相关因素(P<0.05)。老年肺癌患者继发组1年生存率、2年生存率均低于未继发组(P<0.05)。结论老年肺癌患者继发IFI的危险因素可能有营养状况差、放化疗、糖尿病、长期使用抗菌素等,临床需尽早识别继发IFI的相关危险因素,以预防IFI发生。

Objective To investigate the risk factors and prognosis of invasive fungal infections(IFI)in elderly patients with lung cancer.Methods A retrospective study was conducted on 110 elderly lung cancer patients admitted to Sixth People s Hospital of Nantong City from June 2020 to June 2021.According to whether they had secondary IFI,they were divided into secondary group(n=48)and non-secondary group(n=62).The general data of the two groups were compared.Binary Logistic regression analysis was used to explore the related factors of secondary IFI in elderly patients with lung cancer,and the prognosis of the patients was analyzed.Results The proportion of poor nutrition,smoking,TNM stageⅢⅣ,radiotherapy and chemotherapy,diabetes mellitus and long-term use of antibiotics in the secondary group were higher than those in the non-secondary group(P<0.05).There was no statistically significant difference in age and the proportion of patients with hypertension,gender and pathological type between the two groups(P>0.05).Binary Logistic regression analysis showed that poor nutritional status,radiotherapy and chemotherapy,diabetes mellitus and long-term use of antibiotics were the related factors for secondary IFI in elderly patients with lung cancer(P<0.05).The 1-year and 2-year survival rates of the secondary group were lower than those of the non-secondary group(P<0.05).Conclusion The risk factors of secondary IFI in elderly lung cancer patients may include poor nutritional status,radiotherapy and chemotherapy,diabetes mellitus,long-term use of antibiotics,etc.It is necessary to identify these risk factors of secondary IFI as early as possible in clinical practice to prevent the occurrence of IFI.