利培酮联合丙戊酸钠治疗精神分裂症攻击行为的效果及安全性

Effect and Safety of Risperidone Combined with Sodium Valproatein the Treatment of Aggressive Behavior of Schizophrenia

目的探究利培酮联合丙戊酸钠治疗精神分裂症(SP)攻击行为的效果及安全性。方法以2021年3月-2023年3月天津建华医院收治的100例精神分裂症患者为研究对象,经随机数字表法分为对照组(50例)与观察组(50例)。对照组给予利培酮治疗,观察组应用利培酮联合丙戊酸钠治疗,比较两组临床疗效、阳性和阴性症状量表(PANSS)、攻击行为[修订版外显攻击行为量表(MOAS)、精神病患者攻击感知量表(POPAS)]、精神分裂症患者生活质量量表(SQLS)评分及不良反应。结果观察组总有效率高于对照组(P<0.05);两组治疗后PANSS评分低于治疗前,且观察组PANSS评分低于对照组(P<0.05);两组治疗后MOAS、POPAS评分低于治疗前,且观察组MOAS、POPAS评分低于对照组(P<0.05);两组治疗后SQLS评分均低于治疗前,且观察组SQLS评分均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论利培酮联合丙戊酸钠治疗精神分裂症效果确切,可有效减轻患者精神症状,改善其攻击行为,且不增加药物不良反应,有助于患者生活质量的提升。

Objective To explore the effect and safety of risperidone combined with sodium valproate in the treatment of aggressive behavior of schizophrenia(SP).Methods A total of 100 patients with schizophrenia admitted to Tianjin Jianhua Hospital from March 2021 to March 2023 were divided into control group(50 patients)and observation group(50 patients)by random number table method.The control group was treated with risperidone,and the observation group was treated with risperidone combined with sodium valproate.The clinical efficacy,Positive and Negative Symptom Scale(PANSS),aggressive behavior[Modified Overt Aggression Scale(MOAS),Perception of Prevalence of Aggression Scale(POPAS)],Schizophrenia Quality of Life Scale(SQLS)score and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The PANSS score of the two groups after treatment was lower than that before treatment,and the PANSS score of the observation group was lower than that of the control group(P<0.05).The scores of MOAS and POPAS in the two groups after treatment were lower than those before treatment,and the scores of MOAS and POPAS in the observation group were lower than those in the control group(P<0.05).The SQLS scores of the two groups after treatment were lower than those before treatment,and the SQLS scores of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Risperidone combined with sodium valproate is effective in the treatment of schizophrenia,which can effectively reduce the mental symptoms of patients,improve their aggressive behavior,and do not increase adverse drug reactions.Meanwhile,it is helpful to improve the quality of life of patients.