细胞焦亡在肾脏疾病中的作用

Role of Pyroptosis in Renal Diseases

细胞焦亡(pyroptosis)是一种由炎性半胱天冬酶(caspase)引起的炎性程序性细胞死亡方式,主要有经典和非经典两种途径,分别由caspase-1和caspase-4/5/11介导,通过触发gasdermin D(GSDMD),导致细胞膜穿孔,从而释放细胞内容物及相关炎性因子,进而引发细胞焦亡。肾脏相关疾病,例如慢性肾脏病(CKD)、狼疮性肾炎(LN)、糖尿病肾病(DKD)等常常伴有细胞死亡以及急性或慢性的炎症反应。近年来,越来越多的研究对细胞焦亡在肾脏疾病的发生发展中扮演的角色进行了探索和研究。本文简要阐述了细胞焦亡的分子机制,并对细胞焦亡在多种肾脏相关疾病中发挥的作用进行综述,以期为肾脏疾病的治疗提供新思路。

Pyroptosis is an inflammatory programmed cell death mode caused by inflammatory caspase.There are two main pathways,classical and non-classical,mediated by caspase-1 and caspase-4/5/11,respectively.By triggering GSDMD,it leads to cell membrane perforation.This leads to the release of cellular contents and associated inflammatory factors,which in turn triggers pyroptosis.Kidney diseases such as chronic kidney disease(CKD),lupus nephritis(LN),and diabetic kidney disease(DKD)are often accompanied by cell death and acute or chronic inflammatory reactions.In recent years,more and more studies have explored the role of pyroptosis in the occurrence and development of kidney disease.Here,This article briefly describes the molecular mechanism of pyroptosis and reviews the role of pyroptosis in a variety of renal diseases,in order to provide new ideas for the treatment of kidney diseases.