盐酸拉贝洛尔对妊娠期高血压患者胎盘血流灌注的影响

The Effect of Rabelol Hydrochloride on Placental Blood Flow Perfusion in Patients with Gestational Hypertension

目的 探究妊娠期高血压患者给予盐酸拉贝洛尔进行治疗,对胎盘血流灌注有何影响。方法 选取2020年6月至2022年5月期间就诊且有意愿于泉州市第一医院分娩的116例孕晚期高血压患者为受试对象,按照随机数字表法分为观察组与对照组各58例。对照组患者给予常规药物治疗,观察组患者在对照组基础上给予盐酸拉贝洛尔进行治疗。分析比较两组患者治疗前及治疗10周后治疗效果[舒张压(diastolic blood pressure,DBP)、收缩压(systolic blood pressure,SBP)、平均动脉血压(mean arterial pressure,MAP)、24 h蛋白尿]及子宫动脉、脐动脉血流动力学参数[搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期最大速度、舒张末期速度之比(S/D)]及产后状况[不良母婴结局发生率、新生儿窒息程度(Apgar评分)]。结果 干预10周后,患者DBP、SBP、MAP、24 h蛋白尿、子宫两侧动脉与脐动脉的PI、RI、S/D检测水平均下降,且观察组低于对照组(P <0.05);两组患者产后出血率比较无统计学差异(P> 0.05);观察组患者早产率、胎儿窘迫率均低于对照组(P> 0.05);新生儿评分(Activity、Pulse、Grimace、Appearance、Respiration,Apgar)则明显高于对照组(P <0.05)。结论 妊娠期高血压患者给予盐酸拉贝洛尔治疗可以有效控制患者血压,同时增加胎盘血流灌注量,降低不良母婴结局发生率。

Objective To investigate the impact of rabelol hydrochloride treatment on placental blood flow perfusion in patients with gestational hypertension.Methods 116 late pregnancy hypertensive patients who visited our hospital from June 2020 to May 2022 and were willing to give birth were selected as the study subjects.They were randomly divided into an observation group and a control group,with 58 patients in each group.The control group patients were treated with conventional drugs,while the observation group patients were treated with rabelol hydrochloride on the basis of the control group.The therapeutic effects [diastolic blood pressure(DBP),systolic blood pressure(SBP),mean arterial blood pressure(MAP),24-hour proteinuria],uterine artery and umbilical artery hemodynamic parameters [pulsatility index(PI),resistance index(RI),maximum systolic velocity,ratio of end diastolic velocity(S/D)] and postpartum status [incidence of adverse maternal and infant outcomes,degree of neonatal asphyxia(Apgar score)] were analyzed and compared between the two groups before and 10 weeks after treatment.Results After 10 weeks of intervention,the levels of DBP,SBP,MAP,24h proteinuria,PI,RI,S/D of bilateral uterine arteries and umbilical artery in patients decreased,and the levels in the observation group were significantly lower than those in the control group(P<0.05);There was no statistically significant difference in postpartum bleeding rates between the two groups of patients(P>0.05);The premature birth rate and fetal distress rate in the observation group were significantly lower than those in the control group(P>0.05);The Apgar score of newborns was significantly higher than that of the control group(P<0.05).Conclusions Treatment with rabelol hydrochloride in patients with gestational hypertension can effectively control blood pressure,increase placental blood flow perfusion,and reduce the incidence of adverse maternal and infant outcomes.