TH2细胞因子在2型慢性鼻窦炎伴鼻息肉中的作用机制研究进展

Research progress on the role of TH2 cytokines in Type2 chronic rhinosinusitis with nasal polyps

慢性鼻窦炎(chronic rhinosinusitis with nasal polyps,CRS)根据其发病机制可分为2型和非2型炎症内型,其中2型炎症对应于嗜酸性粒细胞浸润为主的慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)。典型的2型CRSwNP患者通常对目前的治疗有耐药性,表现出较高的复发率。尽管生物制剂在其治疗上取得了一定的成功,但靶向单一TH2细胞因子并不能完全消除大多数患者的2型疾病,故靶向阻断TH2细胞因子及其下游的信号转导通路可能是针对内型治疗的一种新思路。论文对各2型细胞因子(IL-4、IL-5、IL-9、IL-13、IL-25和IL-33)在2型CRSwNP中与其特异性受体相互结合后激活的细胞内信号通路进行综述,旨在为治疗2型CRSwNP提供新的靶点。

Chronic rhinosinusitis(CRS)are classified as type 2 and non-type 2 intrainflammatory types according to the pathogenesis,where type 2 inflammation corresponds to chronic rhinosinusitis with nasal polyps(CRSwNP)dominated by eosinophil infiltration.Patients with typical type 2 CRSwNP are typically resistant to current treatments and exhibit high recurrence rates.Although some success has been achieved regarding treatment,targeting a single TH2 cytokine cannot completely eliminate type 2 CRSwNP in most patients.Therefore,targeting the TH2 cytokine and its downstream signal transduction pathway may present a novel approach for endotherapy.In this study,we review the intracellular signaling pathways activated by various type 2 cytokines(IL-4,IL-5,IL-9,IL-13,IL-25,and IL-33)after binding to their specific receptors in type 2 CRSwNP,in order to provide new targets for type 2 CRSwNP therapeutics.