过敏性疾病与糖尿病的相关性及潜在关联机制

Relationship between allergic diseases and diabetes mellitus and underlying mechanisms

过敏性疾病和糖尿病(diabetes mellitus,DM)均是与炎症相关的全身性慢性疾病,二者的症状涉及人体多个器官,发病机制较为复杂。然而过敏性疾病与DM之间的正负相关关系存在很大争议,关联机制研究报道较少。多数研究报道认为DM与过敏性疾病中的哮喘呈正相关,而与变应性鼻炎、特应性皮炎呈负相关。正负相关性差异的产生可能与受试人群来源的国家地区不同有关。过敏性疾病与DM的关联机制尚不完全明确,已经提出的机制以促炎途径和血糖代谢为主。论文综述过敏性疾病与DM的相关流行病学和机制研究,以期增强临床上对于二者共病的认知。

Allergic diseases and diabetes mellitus(DM) are systemic chronic diseases associated with inflammation.Both conditions involve multiple organs and complex pathogenesis.However,current evidence on the relationship between allergic diseases and DM is contradictory,and there have been few reports on associated mechanisms.Most studies have reported that DM was positively associated with asthma in allergic diseases,but negatively associated with allergic rhinitis and atopic dermatitis.The different associations may be due to ethnicity and race differences.The mechanisms associated with allergic diseases and DM are not yet fully understood and may be related to pro-inflammatory pathways and blood glucose metabolism.This article reviews epidemiological and mechanistic studies related to allergic diseases and DM to enhance clinical knowledge of their co-morbidities.