摘要
网格蛋白介导型胞吞作用(clathrin-mediated endocytosis,CME)是代谢产物、激素、蛋白质和某些病毒进入细胞的主要途径.前期研究已报道超过50种胞吞辅助蛋白(endocytic accessory proteins,EAPs)参与到CME的进程中,但是其复杂的分子调控机制仍有待厘清.近年来显微成像技术及CME抑制剂的发展为更好地解析CME的分子机制提供了机会.本文重点介绍了哺乳动物细胞中CME的分阶段调控机制以及CME抑制剂的开发现状.
Clathrin-mediated endocytosis(CME)is the major route for cells to uptake metabolites,hormones,proteins and some viruses.More than 50 endocytic accessory proteins(EAPs)have been reported to be involved in CME;however,its complicated regulation mechanism remains elusive.Recent advances in microscopy imaging and the developments of CME inhibitors provide opportunities to better resolve the molecular mechanism of CME.This work highlights the step-wise regulation mechanism of CME in mammalian cells and introduces the developments of CME inhibitors.
作者
韩璐
贺樟平
杨紫雁
陈志明
HAN Lu;HE ZhangPing;YANG ZiYan;CHEN ZhiMing(Institute of Cytology and Genetics,Hengyang Medical School,University of South China,Hengyang 421001,China;Department of Clinical Laboratory,The First Affiliated Hospital of Hengyang Medical School,University of South China,Hengyang 421001,China;National Health Commission Key Laboratory of Birth Defect Research and Prevention,The Affiliated Maternal and Child Health Care Hospital(Hunan Provincial Maternal and Child Care Hospital),Hengyang Medical School,University of South China,Changsha 410008,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2023年第10期1361-1369,共9页
Scientia Sinica(Vitae)
