风湿骨痛片辅助艾瑞昔布治疗冻结肩的疗效观察

Efficacy of Imrecoxib Assisted with Rheumatic Bone Pain Tablets in Treatment of Frozen Shoulder

目的研究风湿骨痛片辅助艾瑞昔布消炎止痛治疗冻结肩疗效。方法选取2021年1月至2023年2月收治的冻结肩患者,根据信封法随机分为对照组和观察组。对照组采用艾瑞昔布治疗,观察组在对照组基础上给予风湿骨痛片治疗。4周疗程结束后对两组治疗效果、疼痛因子、炎症指标、日常生活能力(ADL)评分、视觉模拟量表(VAS)评分、肩关节活动功能及不良反应发生情况进行统计分析。结果共纳入患者200例,其中对照组99例,观察组101例,两组患者年龄、性别构成及治疗前疼痛因子、血清5-羟色胺(5-HT)、前列腺素E2(PGE2)、血清β-内啡肽(β-EP)、炎症指标差异无统计学意义。观察组治疗有效率(96.04%)高于对照组患者(79.80%)(P<0.05);治疗后两组血清5-HT及PGE2下降,观察组低于照组(P<0.05),两组血清β-EP上升,观察组高于对照组(P<0.05);治疗后两组血清P物质(SP)、红细胞沉降率(ESR)及白细胞介素1β(IL-1β)降低,观察组低于对照组(P<0.05);两组治疗后ADL评分升高,观察组高于对照组(P<0.05);两组治疗后VAS评分下降,观察组低于对照组(P<0.05);治疗后两组前屈、外展、外旋、内旋及后伸角度均增大,观察组高于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论风湿骨痛片辅助艾瑞昔布治疗冻结肩效果更好,能有效改善患者疼痛介质、炎症指标水平以及肩关节活动功能,缓解患者疼痛程度,提高患者日常生活能力。

Objective To study the efficacy of imrecoxib assisted with Rheumatic Bone Pain Tablets in the treatment of frozen shoulder.Methods Frozen shoulder patients admitted to our hospital from January 2021 to February 2023 were selected and divided randomly into control group and observation group.In the control group,patients were treated with imrecoxib,and patients in the observation group received rheumatic bone pain tablets based on the control group.The treatment effects,pain factors,inflammation indicators,daily living ability(ADL)score,visual analog scale(VAS)score,shoulder mobility function and the occurrence of adverse reactions were analyzed after 4 weeks of treatment.Results A total of 200 patients including 99 in the control group and 101 in the observation group showed no statistically significant difference among the age,gender composition,pre-treatment pain factors,serum 5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2),serumβ-endorphin(β-EP)and inflammatory indicators.After treatment,the response rate in the observation group(96.04%)was higher than that in the control group(79.80%)(P<0.05);serum 5-HT and prostaglandin E2(PGE 2)decreased in both groups and were lower in the observation group than in the control group(P<0.05);serumβ-EP increased in both groups and that in the observation group increased more than that in the control group(P<0.05);serum substance P(SP),sedimentation(ESR)and interleukin-1β(IL-1β)decreased in the two groups and that in the observation group was lower than that in the control group(P<0.05);the ADL score increased in both groups,and it was higher in the observation group than that in the control group(P<0.05);the VAS score decreased in both groups,and it was lower in the observation group than that in the control group(P<0.05);the angles of anterior flexion,abduction,external rotation,internal rotation and posterior extension increased and that in the observation group was higher than that in the control group(P<0.05);there was no statistical difference in the overall incidence of adverse effects between the two groups(P>0.05).Conclusion Imrecoxib assisted with Rheumatic Bone Pain Tablet has better efficacy in the treatment of frozen shoulder,which can improve the level of pain mediators,inflammatory indicators and shoulder joint movement function,alleviate the degree of pain,and improve the ability of daily life of patients.